2. Apoptosis
  3. MDM-2/p53 Apoptosis
  4. MDM2-IN-24

MDM2-IN-24 (化合物 A3f) 在三阴型乳腺癌细胞中表现出 MDM2 抑制和 MDMX 激活特性，具有促细胞凋亡 (apoptosis) 和抗增殖活性。

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MDM2-IN-24 Chemical Structure

MDM2-IN-24 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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3.  试用装只面向终端客户。

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MDM2-IN-24 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MDM2-IN-24 (compound A3f) exhibits MDM2-inhibiting and MDMX-activating properties in triple-negative breast cancer (TNBC) cells, with apoptotic and anti-proliferative activities[1].

体外研究
(In Vitro)

MDM2-IN-24 是一种 G 四联体配体，与富含 G 的 MDM2 和 MDMX 序列结合，Kd 分别为 4.9 和 5.2 μM[1]。
MDM2-IN-24 (6 μM) 抑制 MDM2，诱导 TNBC 细胞增殖和细胞凋亡 (apoptosis)[1]。
MDM2-IN-24 (6 μM) 对 HCC1937 具有细胞毒性 (HCC1937 细胞存活率为 27.7%)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MDM2-IN-24 相关抗体:

Real Time qPCR[1]

Cell Line: HCC1937
Concentration: 3 μM
Incubation Time:
Result: Decreased mRNA levels of MDM2 and increased mRNA levels of MDMX.

Western Blot Analysis[1]

Cell Line: HCC1937
Concentration: 0-6 μM
Incubation Time: 24 h
Result: Decreased MDM2 expression, increased levels of MDMX and cleaved caspase-3 in normal HCC1937.
Reactivated cleaved caspase-3 in HCC1937 cells with siMDMX.
分子量

612.33

Formula

C33H25Br2P
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MDM2-IN-24 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDM2-IN-24MDM-2/p53ApoptosisTNBCp53HCC1937Inhibitorinhibitorinhibit

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目录号：
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