2. Apoptosis Epigenetics
  3. Apoptosis Epigenetic Reader Domain
  4. Menin-MLL inhibitor-25

Menin-MLL inhibitor-25 (compound A6) 是一种有效的 Menin-MLL 相互作用抑制剂，IC50 值为0.38 µM。Menin-MLL inhibitor-25 显示出抗增殖活性。Menin-MLL inhibitor-25 诱导细胞凋亡和G0/G1期细胞周期停滞。Menin-MLL inhibitor-25 可逆转分化停滞。

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Menin-MLL inhibitor-25 Chemical Structure

Menin-MLL inhibitor-25 Chemical Structure

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Menin-MLL inhibitor-25 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Menin-MLL inhibitor-25 (compound A6) is a potent Menin-MLL interaction inhibitor with an IC50 value of 0.38 µM. Menin-MLL inhibitor-25 shows anti-proliferative activity. Menin-MLL inhibitor-25 induces apoptosis and cell cycle arrest at G0/G1 phase. Menin-MLL inhibitor-25 reverses the differentiation arrest[1].

体外研究
(In Vitro)

Menin-MLL inhibitor-25 (compound A6) (0-10 µM) 显示出抗增殖活性，对于MV4-11、HL-60、SU-DHL-6 细胞的 IC50 值分别为1.07，>10，6.7 µM< sup>[1]。
Menin-MLL inhibitor-25 (0.1, 1, 10 µM; 24 h) 诱导 MV4-11 细胞凋亡和细胞周期停滞在 G0/G1 期[1]。
Menin-MLL inhibitor-25 (0.1, 0.5 µM; 24, 48 h) 以时间和剂量依赖性方式降低 HOXA9 和 MEIS1 基因表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Menin-MLL inhibitor-25 相关抗体:

Cell Viability Assay[1]

Cell Line: MV4-11, HL-60, SU-DHL-6 cells
Concentration: 0-10 µM
Incubation Time:
Result: Showed anti-proliferation activity with IC50s of 1.07, >10, 6.7 µM for MV4-11, HL-60, SU-DHL-6 cells, respectively.

Apoptosis Analysis[1]

Cell Line: MV4-11 cells
Concentration: 0.1, 1, 10 µM
Incubation Time: 24 h
Result: Induced apoptosis with the apoptosis rates of 6.09 %, 8.86 % and 43.08 % at 0.1, 1 and 10 μM.

Cell Cycle Analysis[1]

Cell Line: MV4-11 cells
Concentration: 0.01, 0.1, 1 µM
Incubation Time: 24 h
Result: Induced cell cycle arrest at G0/G1 phase in a dose-dependent manner.

RT-PCR[1]

Cell Line: MV4-11 cells
Concentration: 0.1, 0.5 µM
Incubation Time: 24, 48 h
Result: Decreasesd the gene expression of HOXA9 and MEIS1 in a time and dose dependent manner.
分子量

481.57

Formula

C28H28FN7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Menin-MLL inhibitor-25 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Menin-MLL inhibitor-25ApoptosisEpigenetic Reader DomainMV4-11 cellsapoptosisG0/G1anti-proliferativedifferentiation arrestInhibitorinhibitorinhibit

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目录号：
HY-157814
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