Menthol-d₂ 

Menthol-d₂ is deuterated labeled trans-2,cis-6-Nonadienal (HY-W127515). Trans-2, cis-6-NonadienalIt is an organic compound belonging to aldehydes. It has a strong, pungent smell and is commonly found in a variety of foods, including fruits and vegetables. Trans-2, cis-6-NonadienalIt has a variety of applications in the flavor and fragrance industry, especially as a fragrance agent in products such as perfume, cologne and air fresheners. In addition, it can also be used as an intermediate in the synthesis of various chemicals and drugs.

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Menthol (10-200 μg/mL; po; 单剂量) 可以减少小鼠口服尼古丁 (200 μg/mL) 的厌恶作用，并且在较高浓度下，Menthol 本身会产生刺激物^[3]。
Menthol 还通过 TRPM8 可以强烈抑制呼吸道刺激反应，并且会增加血液中的可替宁。Menthol 作为卷烟添加剂，可能会促进吸烟和尼古丁成瘾^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

158.28

C₁₀H₁₈D₂O

1335435-38-5

1490-04-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. NicolettaGaleotti, et al. Menthol: a natural analgesic compound. Neuroscience Letters. 2002 Apr.

  [3]. Ha MA, et al. Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice. PLoS One. 2015 Feb 13;10(2):e0117128.  [Content Brief]

  [4]. Fan L, et al. Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism. Tob Control. 2016 Nov;25(Suppl 2):ii50-ii54.  [Content Brief]