1. Immunology/Inflammation
  2. Interleukin Related
  3. Mepolizumab

Mepolizumab  (Synonyms: 美泊利单抗; SB 240563)

目录号: HY-P9945 纯度: 98.00%
COA 技术支持

Mepolizumab (SB 240563) 是一种人源化的单克隆抗体,可结合并中和白细胞介素 5 (IL-5),白细胞介素 5 (IL-5) 是参与嗜酸性粒细胞增殖、活化和存活的主要细胞因子。Mepolizumab 可用于嗜酸性肉芽肿伴多血管炎 (EGPA) 和重度嗜酸性哮喘的研究。

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CAS No. : 196078-29-2

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     可免费申领三个不同产品的试用装。

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规格 价格 是否有货 数量
1 mg ¥1800
In-stock
5 mg ¥4500
In-stock
10 mg   询价  
50 mg   询价  

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Other Forms of Mepolizumab:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mepolizumab (SB 240563) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5 (IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma[1][2].

同型

Human IgG1 kappa

推荐同型对照抗体
种属

Humanized

体外研究
(In Vitro)

Mepolizumab shows nearly linear PK after intravenous administration over a 6000-fold dose range (0.05-300 mg/kg), inhibiting eosinophil proliferation with an IC50 of 1.43 mg/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Mepolizumab 静脉给药超过 6000 倍剂量范围 (0.05-300 mg/kg) 后,观察到近似线性的 PK,抑制嗜酸性粒细胞增殖,IC50 为 1.43 mg/mL[1]
Mepolizumab 在食蟹猴体内的药代动力学分析[1]

Route Dose (mg/kg) Cmax (μg/mL) AUC0-INF_obs (μg·h/mL) T1/2 (days) Clobs (mL·h/kg) Vss_obs (mL/kg)
i.v. 300 6700 1405000 11.7 0.217 74.6
i.v. 3 89.1 14600 11.2 0.208 82.1

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

美泊利单抗; 美泊丽珠单抗

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Mepolizumab
目录号:
HY-P9945
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