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  4. Migrastatin

Migrastatin 是一种典型的 Fascin1 抑制剂。Migrastatin 是从链霉菌属 MK929-43F1 的培养液中分离出来的。Migrastatin 抑制肿瘤细胞迁移。

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Migrastatin Chemical Structure

Migrastatin Chemical Structure

CAS No. : 314245-65-3

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1 mg ￥16425
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Migrastatin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Migrastatin is a typical Fascin1 inhibitor. Migrastatin is isolated from a cultured broth of Streptomyces sp. MK929-43F1. Migrastatin inhibits tumor cell migration[1][2].

IC50 & Target

Fascin1[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
4T1 IC50
14 μM
Compound: 3, migrastatin
Inhibition of cell migration of mouse 4T1 cells after 4 days by scratch wound healing assay
Inhibition of cell migration of mouse 4T1 cells after 4 days by scratch wound healing assay
[PMID: 18684620]
MDA-MB-231 IC50
17 μM
Compound: 3, migrastatin
Inhibition of human MDA-MB-231 cell migration after 4 days by scratch wound healing assay
Inhibition of human MDA-MB-231 cell migration after 4 days by scratch wound healing assay
[PMID: 18684620]
体外研究
(In Vitro)

Migrastatin (100 μM) leads to the disorganization of the bundles. Migrastatin (100 μM; HCT-116 and DLD-1 cells) prevents cell migration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Migrastatin 相关抗体:
分子量

489.60

Formula

C27H39NO7
CAS 号
结构分类
初始来源

Streptomyces sp. MK929-43F1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Migrastatin 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Migrastatin314245-65-3OtherstypicalStreptomycesMK929-43F1tumormigrationcancerInhibitorinhibitorinhibit

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目录号：
HY-121452
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