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(-)-Cryptopleurine  (Synonyms: (R)-Cryptopleurine; NSC 19912)

目录号: HY-121255
产品使用指南

摩尔计算器

(–)-Cryptopleurine 是一种存在于樟科植物中的生物碱，具有多种生物活性。它可抑制人类 A375 黑色素瘤、A431 表皮样癌、A549 肺癌、MES-SA 子宫肉瘤和 MCF-7 乳腺癌细胞的生长（所有细胞的 IC50=3 nM）。(–)-Cryptopleurine 可在缺氧反应元件 (HRE) 报告基因检测中抑制缺氧诱导的基因表达（IC50=8.7 nM）。(–)-Cryptopleurine (500 μg/ml) 可防止感染烟草花叶病毒 (TMV) 的烟草 (N. tabacum) 植物形成病变。它还可抑制酵母和哺乳动物核糖体的蛋白质合成。

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(-)-Cryptopleurine Chemical Structure

(-)-Cryptopleurine Chemical Structure

CAS No. : 482-22-4

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(-)-Cryptopleurine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(–)-Cryptopleurine is an alkaloid that has been found in Lauraceae and has diverse biological activities. It inhibits the growth of human A375 melanoma, A431 epidermoid carcinoma, A549 lung, MES-SA uterine sarcoma, and MCF-7 breast cancer cells (IC50=3 nM for all).2 (–)-Cryptopleurine inhibits hypoxia-induced gene expression in a hypoxia response element (HRE) reporter assay (IC50=8.7 nM).3 (–)-Cryptopleurine (500 μg/mL) prevents lesion formation in tobacco (N. tabacum) plants infected with tobacco mosaic virus (TMV). It also inhibits protein synthesis by yeast and mammalian ribosomes.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-375 IC50
1.2 nM
Compound: (-)-1
Antiproliferative activity against human A375 cells after 72 hrs by ATPlite assay
Antiproliferative activity against human A375 cells after 72 hrs by ATPlite assay
[PMID: 25499434]
A549 GI50
< 0.001 μM
Compound: 36
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 22417638]
A549 IC50
0.94 nM
Compound: 2
Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by SRB assay
[PMID: 26393416]
A549 GI50
1.38 nM
Compound: R-cryptopleurine
Anticancer activity against human A549 cells after 72 hrs by sulforhodamine B assay
Anticancer activity against human A549 cells after 72 hrs by sulforhodamine B assay
[PMID: 21668000]
A549 IC50
1.38 nM
Compound: cryptopleurine
Cytotoxicity against human A549 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis
Cytotoxicity against human A549 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis
[PMID: 22823514]
A549 IC50
1.9 nM
Compound: (-)-1
Antiproliferative activity against human A549 cells after 72 hrs by ATPlite assay
Antiproliferative activity against human A549 cells after 72 hrs by ATPlite assay
[PMID: 25499434]
A549 IC50
1.9 nM
Compound: cryptopleurine
Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by SRB assay
Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by SRB assay
[PMID: 22823514]
AGS IC50
8.7 nM
Compound: 1
Inhibition of hypoxia-induced HIF1 activation in human AGS cells after 16 hrs by pGL3-HRE-luciferase reporter gene assay
Inhibition of hypoxia-induced HIF1 activation in human AGS cells after 16 hrs by pGL3-HRE-luciferase reporter gene assay
[PMID: 16872154]
CAKI-1 IC50
0.86 nM
Compound: 2
Cytotoxicity against human Caki1 cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human Caki1 cells assessed as growth inhibition after 72 hrs by SRB assay
[PMID: 26393416]
CL1-0 IC50
5 nM
Compound: cryptopleurine
Cytotoxicity against human CL1-0 cells assessed as cell viability after 48 hrs by SRB assay
Cytotoxicity against human CL1-0 cells assessed as cell viability after 48 hrs by SRB assay
[PMID: 22823514]
DU-145 GI50
1.59 nM
Compound: R-cryptopleurine
Anticancer activity against human DU145 cells after 72 hrs by sulforhodamine B assay
Anticancer activity against human DU145 cells after 72 hrs by sulforhodamine B assay
[PMID: 21668000]
DU-145 IC50
1.59 nM
Compound: cryptopleurine
Cytotoxicity against human DU145 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis
Cytotoxicity against human DU145 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis
[PMID: 22823514]
HCT-116 IC50
0.7 nM
Compound: (-)-1
Antiproliferative activity against human HCT116 cells after 72 hrs by ATPlite assay
Antiproliferative activity against human HCT116 cells after 72 hrs by ATPlite assay
[PMID: 25499434]
HCT-116 IC50
1.04 nM
Compound: 2
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by SRB assay
[PMID: 26393416]
HCT-8 GI50
1.09 nM
Compound: R-cryptopleurine
Anticancer activity against human HCT8 cells after 72 hrs by sulforhodamine B assay
Anticancer activity against human HCT8 cells after 72 hrs by sulforhodamine B assay
[PMID: 21668000]
HCT-8 IC50
1.91 nM
Compound: cryptopleurine
Cytotoxicity against human HCT8 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis
Cytotoxicity against human HCT8 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis
[PMID: 22823514]
HL-60 GI50
< 0.001 μM
Compound: 36
Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
[PMID: 22417638]
KB GI50
1.51 nM
Compound: R-cryptopleurine
Anticancer activity against human KB cells after 72 hrs by sulforhodamine B assay
Anticancer activity against human KB cells after 72 hrs by sulforhodamine B assay
[PMID: 21668000]
KB IC50
1.51 nM
Compound: cryptopleurine
Cytotoxicity against human KB cells after 2 hrs by methylene blue staining-based spectrophotometric analysis
Cytotoxicity against human KB cells after 2 hrs by methylene blue staining-based spectrophotometric analysis
[PMID: 22823514]
MDA-MB-231 IC50
0.89 nM
Compound: 2
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by SRB assay
[PMID: 26393416]
MRC5 IC50
14 nM
Compound: cryptopleurine
Cytotoxicity against human MRC5 cells assessed as cell viability after 48 hrs by SRB assay
Cytotoxicity against human MRC5 cells assessed as cell viability after 48 hrs by SRB assay
[PMID: 22823514]
NAMALVA IC50
2.6 nM
Compound: (-)-1
Antiproliferative activity against human NAMALWA cells after 72 hrs by ATPlite assay
Antiproliferative activity against human NAMALWA cells after 72 hrs by ATPlite assay
[PMID: 25499434]
PC-3 IC50
2.55 nM
Compound: 2
Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by SRB assay
[PMID: 26393416]
PC-9 IC50
5.5 nM
Compound: cryptopleurine
Cytotoxicity against human PC9 cells assessed as cell viability after 48 hrs by SRB assay
Cytotoxicity against human PC9 cells assessed as cell viability after 48 hrs by SRB assay
[PMID: 22823514]
SK-HEP1 IC50
0.83 nM
Compound: 2
Cytotoxicity against human SKHEP1 cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human SKHEP1 cells assessed as growth inhibition after 72 hrs by SRB assay
[PMID: 26393416]
SNU-638 IC50
1.26 nM
Compound: 2
Cytotoxicity against human SNU638 cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human SNU638 cells assessed as growth inhibition after 72 hrs by SRB assay
[PMID: 26393416]
分子量

377.48

Formula

C24H27NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(-)-Cryptopleurine 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Cryptopleurine482-22-4(R)-Cryptopleurine NSC 19912NSC19912NSC 19912NSC-19912OthersInhibitorinhibitorinhibit

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