2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. (-)-Isodocarpin

(-)-Isodocarpin  (Synonyms: 大萼香茶菜甲素; Isodocarpin)

目录号: HY-134046
产品使用指南 技术支持

(-)-Isodocarpin (Isodocarpin) 是一种二萜类化合物，是一种有效的黑色素生成 (melanogenesis) 抑制剂，在 B16 4A5 细胞中的 IC50 为 0.19 μM。(-)-Isodocarpin 抑制酪氨酸酶、酪氨酸相关蛋白 (TRP)-1 和 TRP-2 mRNA 的表达。

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(-)-Isodocarpin Chemical Structure

(-)-Isodocarpin Chemical Structure

CAS No. : 10391-08-9

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规格 价格 是否有货 数量
1 mg ￥3600
1 - 2 周
5 mg 现货 1 - 2 周
10 mg   询价  
50 mg   询价  

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(-)-Isodocarpin 相关抗体

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MC1R MC3R MC2R MC4R MC5R

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC50 of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
3.2 μM
Compound: 14
Cytotoxicity against human A549 cells after 48 hrs by MTS assay
Cytotoxicity against human A549 cells after 48 hrs by MTS assay
[PMID: 24219809]
HL-60 IC50
2.8 μM
Compound: 14
Cytotoxicity against human HL60 cells after 48 hrs by MTS assay
Cytotoxicity against human HL60 cells after 48 hrs by MTS assay
[PMID: 24219809]
MCF7 IC50
2.6 μM
Compound: 14
Cytotoxicity against human MCF7 cells after 48 hrs by MTS assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTS assay
[PMID: 24219809]
RAW264.7 IC50
2.2 μM
Compound: 14
Inhibition of LPS-stimulated NO production in mouse RAW264.7 cells after 18 hrs by Griess assay
Inhibition of LPS-stimulated NO production in mouse RAW264.7 cells after 18 hrs by Griess assay
[PMID: 24219809]
SMMC-7721 IC50
3.5 μM
Compound: 14
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTS assay
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTS assay
[PMID: 24219809]
SW480 IC50
1 μM
Compound: 14
Cytotoxicity against human SW480 cells after 48 hrs by MTS assay
Cytotoxicity against human SW480 cells after 48 hrs by MTS assay
[PMID: 24219809]
分子量

346.42

Formula

C20H26O5
CAS 号
中文名称

大萼香茶菜甲素
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(-)-Isodocarpin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Isodocarpin10391-08-9Isodocarpin大萼香茶菜甲素Melanocortin ReceptorMC ReceptorditerpenoidmelanogenesisB16 4A5 celltyrosinasetyrosine-related proteinTRP-1TRP-2Inhibitorinhibitorinhibit

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