2. Metabolic Enzyme/Protease
  3. Glucokinase
  4. MK-0941 free base

MK-0941 free base 是具有口服活性的葡糖激酶 (glucokinase) 激活剂，在葡萄糖浓度为 2.5 和 10 mM 的条件下，对重组人 glucokinase 的 EC50 值分别为 240 和 65 nM。MK-0941 free base 具有较强的降血糖活性，是研究 2 型糖尿病的候选活性分子。

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MK-0941 free base Chemical Structure

MK-0941 free base Chemical Structure

CAS No. : 752240-01-0

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MK-0941 free base 的其他形式现货产品:

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MK-0941 free base 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MK-0941 free base is an orally active glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 free base exhibits strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes[1][2].

IC50 & Target

Glucokinase[1][2].
体内研究
(In Vivo)

MK-0941 free base (3 or 10 mg/kg, sing oral dose) treatment reduced blood glucose significantly in db/db diabetic mouse[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male db/db and db/+ (lean) mice (9-10 weeks of age, weighing 43-45 g) [1].
Dosage: 3 or 10 mg/kg.
Administration: Oral gavage, single dose.
Result: Resulted in significant reduction in blood glucose. These two doses lowered blood glucose similarly at 1 h after dosing, suggesting that saturation of effect was approached.
Clinical Trial
分子量

460.50

Formula

C21H24N4O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MK-0941 free base 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-0941752240-01-0MK0941MK 0941GlucokinaseHexokinase IVHexokinase DInhibitorinhibitorinhibit

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目录号：
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