2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. ML-7

ML-7是一种肌球蛋白轻链激酶抑制剂，具有抑制人类中性粒细胞中超氧阴离子(O(2)(-))的释放活性。ML-7能在不依赖肌球蛋白轻链激酶的情况下，影响中性粒细胞的活性。ML-7抑制了刺激细胞的细胞外O(2)(-)释放，但对细胞内O(2)(-)的产生没有影响。ML-7还强烈抑制了氧化物产生的细胞内区室与细胞膜的结合，表明其在刺激的中性粒细胞中起到了关键作用。同时，ML-7保护心脏功能避免缺血/再灌注损伤。

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ML-7 Chemical Structure

ML-7 Chemical Structure

CAS No. : 109376-83-2

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ML-7 的其他形式现货产品:

Customer Review

Other Forms of ML-7:

ML-7 相关抗体

Top Publications Citing Use of Products

    ML-7 purchased from MCE. Usage Cited in: Int J Mol Sci. 2023 Mar 27.

    ML-7 hydrochloride (ML-7; 10 μM; 2 h; pretreatment) significantly reduces the protein level of phosphorylated MLC2 and the phosphorylation ratio of MLC2 in BMECs.

    ML-7 purchased from MCE. Usage Cited in: J Agric Food Chem. 2021 Mar 22.  [Abstract]

    Relative protein expression of ZO-1 pretreated with 10 μmol/L ML7 for 1 h. ML7 directly inhibits the expression of ZO-1.

    ML-7 purchased from MCE. Usage Cited in: Toxicol Lett. 2020 Oct 10;332:146-154.  [Abstract]

    Cells are incubated with 10 μM ML-7 for 1 h, followed by incubation with 1.0 μM As2O3 for 24 h and assessment of occludin protein expression with Western blotting.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    ML-7 is a myosin light chain kinase inhibitor with the activity to inhibit superoxide anion (O(2)(-)) release in human neutrophils. ML-7 can affect the activity of neutrophils independently of myosin light chain kinase. ML-7 inhibits the extracellular O(2)(-) release of stimulated cells, but has no effect on the intracellular O(2)(-) production. ML-7 also strongly inhibits the binding of the intracellular compartment of oxide production to the cell membrane, indicating that it plays a key role in stimulated neutrophils. At the same time, ML-7 protects cardiac function from ischemia/reperfusion injury[1].

    分子量

    416.28

    Formula

    C15H17IN2O2S
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    ML-7 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    ML-7109376-83-2ML7ML 7Endogenous MetaboliteInhibitorinhibitorinhibit

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    产品名称：
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    目录号：
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