2. Anti-infection
  3. SARS-CoV
  4. ML2006a4

ML2006a4 是具有口服活性的 SARS-CoV-2 主要蛋白酶 (Mpro) 抑制剂，IC50 值为纳摩尔级。ML2006a4 具有细胞渗透性和抗病毒活性，可在纳摩尔水平抑制 Huh7.5.1-ACE2-TMPRSS2 (Huh7.5.1++) 细胞中 SARS-CoV-2 的复制。

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ML2006a4 Chemical Structure

ML2006a4 Chemical Structure

CAS No. : 2943213-62-3

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

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ML2006a4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ML2006a4 is an orally active inhibitor for SARS-CoV-2 main protease (Mpro) with IC50 in picomolare value. ML2006a4 is cell permeable and antiviral active, that inhibits replication in SARS-CoV-2 in cells Huh7.5.1-ACE2-TMPRSS2 (Huh7.5.1++) in picomolare level[1]

体外研究
(In Vitro)

ML2006a4 (0-10 μM) 在细胞 Huh7.5.1++ 和 A549-ACE2 (A549+) 中具有抗病毒活性，EC50 分别为 100 和 120 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ML2006a4 相关抗体:
体内研究
(In Vivo)

ML2006a4 (20 mg/kg，静脉注射) 的药代动力学曲线显示，ML2006a4 的血浆清除率 Cpl 为 39 mL/min/kg，稳态分布容积 Vss 0.66 L/kg，口服生物利用度为 27% (40 mg/kg，口服)[1]。
ML2006a4 (40 mg/kg，口服，每天 2 次，共 4 天) 可改善 SARS-CoV-2 感染，对 BALB/c 小鼠表现出病毒抑制和肺保护作用，且无明显毒性[1] 。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SARS-CoV-2 MA10 infected BALB/c mice[1]
Dosage: 40 mg/kg
Administration: p.o., twice a day for 4 days
Result: Reduced inflammation and respioratory epithelial injury, improved epithelial regeneration and the survival rates with minimal weight loss.
分子量

627.70

Formula

C30H44F3N5O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ML2006a4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML2006a42943213-62-3SARS-CoVSARS coronavirusSARS-CoV-2BALB/c mouseHuh7.5.1A549Inhibitorinhibitorinhibit

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