2. Anti-infection
  3. Bacterial
  4. MmpL3-IN-1

MmpL3-IN-1 (compound 32) 是一种有效的霉菌膜大型蛋白 3 (MmpL3) 抑制剂。MmpL3-IN-1 具有抗结核活性，作用于 M. tuberculosis 的 MIC < 0.016 μg/mL，可用于耐药结核病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

MmpL3-IN-1 Chemical Structure

MmpL3-IN-1 Chemical Structure

CAS No. : 2290534-93-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

MmpL3-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MmpL3-IN-1 (compound 32) is a potent Mycobacterial membrane protein large 3 (MmpL3) inhibitor. MmpL3-IN-1 has anti-tuberculosis activity with the MIC<0.016 μg/mL in M. tuberculosis and can be used in studies of drug-resistant tuberculosis[1].

体外研究
(In Vitro)

MmpL3-IN-1 (compound 32) (0.26-64 μg/mL, 2-7days) has potent anti-M. tuberculosis activity with the MIC value of less than 0.016 μg/mL and with almost non-toxic to Vero cells[1].
MmpL3-IN-1 has good microsomal stability and little inhibition of hERG K+ channels with the IC50 value of more than 30 μM[1].
MmpL3-IN-1 (0.0625-1 μg/mL, 16 h) can inhibit TMM transport by targeting MmpL3, thereby affecting the formation of the cell wall of M. tuberculosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MmpL3-IN-1 相关抗体:

Cell Viability Assay[1]

Cell Line: Vero cells
Concentration: 0.26-64 μg/mL
Incubation Time: 48 hours
Result: Inhibited cell viability with an IC50 value of 35.3 μg/mL.

Western Blot Analysis[1]

Cell Line: M. tuberculosis H37Rv mc2 6206
Concentration: 0.0625-1 μg/mL
Incubation Time: 16 hours
Result: Resulted in the accumulation of alginate monomycin (TMM) expression and reduced cell wall-bound mycolic acid methyl esters (MAMEs) in a dose-dependent manner.
Reduced synthesis of alginate dimycolate (TDM), together with accumulation of free mycolate at high concentration.
体内研究
(In Vivo)

MmpL3-IN-1 (compound 32) (oral gavage, 100 mg/kg, 5 days per week, 30 days) has effective anti-tuberculosis activity in SPF BALB/c female mice with H37Rv[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SPF BALB/c female mice with H37Rv[1]
Dosage: 100 mg/kg
Administration: Oral gavage; 5 days per week; 30 days
Result: Showed a 2.0 log CFU reduction of H37Rv in lung colony forming units.
Animal Model: BALB/c mouse (female) weighing 20-25 g[1]
Dosage:
Administration: 100 mg/kg p.o. or 10 mg/kg i.v. ; 0-24 hours
Result: b>The pharmacokinetic parameters of MmpL3-IN-1 (compound 32)
Parameter iv, 10 mg/kg po, 100 mg/kg
t1/2(h) 7.37 7.48
Cmax (ng/mL) 5105 211
Tmax(h) 0.03 0.5
AUC0-t(h•ng/mL) 2475 1625
MRT0-t(h•ng/mL) 2.00 8.69
V (mL/kg) 42067 -
CL (mL/h/kg) 3958 -
F% - 6.6
分子量

357.40

Formula

C20H21F2N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MmpL3-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MmpL3-IN-12290534-93-7BacterialMmpL3 inhibitorM. tuberculosisanti-tuberculosisdrug-resistant tuberculosisInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
MmpL3-IN-1
目录号：
HY-150967
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z