2. MAPK/ERK Pathway
  3. MNK
  4. MNK1/2-IN-8

MNK1/2-IN-8 (compound 15b) 是一种 MNK1/2 抑制剂，对 Mnk1 和 Mnk2 的 IC50 值分别为 0.8 和 1.5 nM。MNK1/2-IN-8 表现出抗增殖活性并诱导细胞周期阻滞。

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MNK1/2-IN-8 Chemical Structure

MNK1/2-IN-8 Chemical Structure

CAS No. : 2430793-35-2

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MNK1/2-IN-8 相关抗体

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查看 MNK 亚型特异性产品:

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MNK1 MNK2 MNK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MNK1/2-IN-8 (compound 15b) is a MNK1/2 inhibitor with the IC50 values of 0.8 and 1.5 nM against Mnk1 and Mnk2. MNK1/2-IN-8 shows anti-proliferative activity and induces cell cycle arrest[1].

IC50 & Target

MNK1

0.8 nM (IC50)

MNK2

1.5 nM (IC50)

体外研究
(In Vitro)

MNK1/2-IN-8 (compound 15b) 对 HCT-116、MOLM-13、K562 和 HL-60 的 GI50 值分别为 7.68、1.59、3.60 和 2.39 μM [1]。
MNK1/2-IN-8 (compound 15b) (1、2和4μM, 24 h) 诱导 MOLM-13 和 K562 细胞系细胞发生周期阻滞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MNK1/2-IN-8 相关抗体:
体内研究
(In Vivo)

MNK1/2-IN-8 (compound 15b) 在小鼠肺癌 LL/2 细胞异种移植模型中抑制肿瘤生长[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

436.51

Formula

C26H24N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MNK1/2-IN-8 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MNK1/2-IN-82430793-35-2MNKMitogen activated protein kinase interacting kinaseMAP kinase interacting kinaseMAPK interacting kinaseMOLM-13K562cell cycleLL/2 syngeneic modelHCT-116HL-60Inhibitorinhibitorinhibit

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