1. Neuronal Signaling
  2. Monoamine Oxidase
  3. Monoamine Oxidase B inhibitor 1

Monoamine Oxidase B inhibitor 1 

目录号: HY-143244
产品使用指南

Monoamine Oxidase B inhibitor 1 是一种有效、可逆,具有口服活性的和选择性的单胺氧化酶 B (MAO-B) 抑制剂,IC50 为 0.02 nM。Monoamine Oxidase B inhibitor 1 具有抗氧化和抗神经炎症活性。Monoamine Oxidase B inhibitor 1 可以穿过血脑屏障 (BBB),可用于帕金森病研究。

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Monoamine Oxidase B inhibitor 1 Chemical Structure

Monoamine Oxidase B inhibitor 1 Chemical Structure

CAS No. : 2807477-70-7

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查看 Monoamine Oxidase 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Monoamine Oxidase B inhibitor 1 is a potent, reversible, orally active and selective monoamine oxidase B (MAO-B) inhibitor with an IC50 of 0.02 nM. Monoamine Oxidase B inhibitor 1 has antioxidant and anti-neuroinflammatory activities. Monoamine Oxidase B inhibitor 1 can across the blood-brain barrier (BBB), and can be used for Parkinson’s disease study[1].

IC50 & Target[1]

MAO-B

0.02 nM (IC50)

MAO-A

810 nM (IC50)

体外研究
(In Vitro)

In cellular experiments, Monoamine Oxidase B inhibitor 1 (compound 14a; 0.5-10.0 μM) could significantly decrease the production of NO and TNF-α in LPS-stimulated BV-2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

In in vivo acute and subacute MPTP-induced mice model of Parkinson’s disease, Monoamine Oxidase B inhibitor 1 (compound 14a; 6-37.4 mg/kg; oral administration) could significantly improve most behavioral disorders, restore the dopamine content and decrease the MDA content in the mice striatum[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

298.31

Formula

C18H15FO3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Monoamine Oxidase B inhibitor 1 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Monoamine Oxidase B inhibitor 1
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HY-143244
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