2. Neuronal Signaling
  3. Monoamine Oxidase
  4. Monoamine Oxidase B inhibitor 5

Monoamine Oxidase B inhibitor 5 

目录号: HY-162573
产品使用指南

摩尔计算器

Monoamine Oxidase B inhibitor 5 (Compound 16d) 是一种可逆性的单胺氧化酶 B (hMAO-B) 选择性抑制剂，IC50 为 67.3 nM，Ki 为 82.5 nM。Monoamine Oxidase B inhibitor 5 在大鼠模型中表现出良好的药代动力学特征和弱毒性。Monoamine Oxidase B inhibitor 5 可缓解帕金森小鼠模型中 MPTP-(HY-15608) 诱发的运动障碍。Monoamine Oxidase B inhibitor 5 具有透血脑屏障 (BBB) 通透性。

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Monoamine Oxidase B inhibitor 5 Chemical Structure

Monoamine Oxidase B inhibitor 5 Chemical Structure

CAS No. : 2969160-15-2

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Monoamine Oxidase B inhibitor 5 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Monoamine Oxidase B inhibitor 5 (Compound 16d) is a selective and reversible inhibitor for monoamine oxidase B (hMAO-B) with an IC50 of 67.3 nM and a Ki of 82.5 nM. Monoamine Oxidase B inhibitor 5 exhibits good pharmacokinetic characters and weak toxicity in rats model. Monoamine Oxidase B inhibitor 5 alleviates MPTP-induced (HY-15608) motor impairment in Parkinson’s mouse model. Monoamine Oxidase B inhibitor 5 is blood-brain barrier (BBB) penetrate[1].

IC50 & Target

hMAO-B

67.3 nM (IC50)

hMAO-A

26014 nM (IC50)

分子量

299.30

Formula

C16H14FN3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Monoamine Oxidase B inhibitor 5 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Monoamine Oxidase B inhibitor 52969160-15-2Monoamine Oxidase B inhibitor5Monoamine Oxidase B inhibitor-5Monoamine OxidaseMAOParkinson's diseasePDsafinamidePC12Inhibitorinhibitorinhibit

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