2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. MOR agonist-4

MOR agonist-4 (2d) 是一种 G 蛋白信号偏倚的 Kappa opioid receptor (KOR) 激动剂，EC50 值为 11 nM。MOR agonist-4 含有一个基于三唑的吸电子的 CF3 基团和偏置因子 38。MOR agonist-4 用于瘙痒和镇痛。

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MOR agonist-4 Chemical Structure

MOR agonist-4 Chemical Structure

CAS No. : 3050669-97-8

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MOR agonist-4 相关抗体

Top Publications Citing Use of Products

查看 Opioid Receptor 亚型特异性产品:

查看所有亚型
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • 生物活性

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  • 参考文献

生物活性

MOR agonist-4 (2d) is a G protein signaling-biased Kappa opioid receptor (KOR) agonist with an EC50 value of 11 nM. MOR agonist-4 contains an electron withdrawing CF3 group and a bias factor of 38 based on triazole. MOR agonist-4 is used in the research of pruritis and analgesia[1].

体外研究
(In Vitro)

MOR agonist-4 (10 μM) 完全抑制了 KOR 与合适的放射性标记受体配体 U69,593 的结合，其 Ki 值为 5.8 nM，但配体与 MOR 和 DOR 的结合较差 (分别为 30.9% 和 30.7%)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MOR agonist-4 相关抗体:
分子量

428.47

Formula

C22H19F3N4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MOR agonist-4 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

MOR agonist-43050669-97-8MOR agonist4MOR agonist 4Opioid ReceptorG protein signalingKORGTPγStriazolepruritisanalgesiaInhibitorinhibitorinhibit

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