2. Cell Cycle/DNA Damage Cytoskeleton
  3. Mps1
  4. Mps1-IN-4

Mps1-IN-4 是一种选择性的 Monopolar spindle 1 (Mps1)抑制剂，具有抗增殖活性，可用于癌症研究。

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Mps1-IN-4 Chemical Structure

Mps1-IN-4 Chemical Structure

CAS No. : 1263423-94-4

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Mps1-IN-4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mps1-IN-4 is a selective Monopolar spindle 1 (Mps1) inhibitor with antiproliferative activity for cancer research[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
6 nM
Compound: 27f
Antiproliferative activity against human A549 cells after 72 hrs by WST8 assay
Antiproliferative activity against human A549 cells after 72 hrs by WST8 assay
[PMID: 25625617]
A549 IC50
6 nM
Compound: 33
Antiproliferative activity against human A549 cells after 96 hrs by crystal violet staining-bsed FACS analysis
Antiproliferative activity against human A549 cells after 96 hrs by crystal violet staining-bsed FACS analysis
[PMID: 31121430]
HCT-116 IC50
9.4 nM
Compound: 27f
Antiproliferative activity against human HCT116 cells after 72 hrs by WST8 assay
Antiproliferative activity against human HCT116 cells after 72 hrs by WST8 assay
[PMID: 25625617]
HCT-15 IC50
6.3 nM
Compound: 27f
Antiproliferative activity against human HCT15 cells after 72 hrs by WST8 assay
Antiproliferative activity against human HCT15 cells after 72 hrs by WST8 assay
[PMID: 25625617]
HL-60 IC50
9.1 nM
Compound: 27f
Antiproliferative activity against human HL60 cells after 72 hrs by WST8 assay
Antiproliferative activity against human HL60 cells after 72 hrs by WST8 assay
[PMID: 25625617]
HT-29 IC50
16 nM
Compound: 27f
Antiproliferative activity against human HT-29 cells after 72 hrs by WST8 assay
Antiproliferative activity against human HT-29 cells after 72 hrs by WST8 assay
[PMID: 25625617]
LC-2-ad IC50
17 nM
Compound: 27f
Antiproliferative activity against human LC2/ad cells after 72 hrs by WST8 assay
Antiproliferative activity against human LC2/ad cells after 72 hrs by WST8 assay
[PMID: 25625617]
LU-99A IC50
4.7 nM
Compound: 27f
Antiproliferative activity against human LU99A cells after 72 hrs by WST8 assay
Antiproliferative activity against human LU99A cells after 72 hrs by WST8 assay
[PMID: 25625617]
MIA PaCa-2 IC50
8.1 nM
Compound: 27f
Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by WST8 assay
Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by WST8 assay
[PMID: 25625617]
MKN-45 IC50
3.3 nM
Compound: 27f
Antiproliferative activity against human MKN45 cells after 72 hrs by WST8 assay
Antiproliferative activity against human MKN45 cells after 72 hrs by WST8 assay
[PMID: 25625617]
MRC5 IC50
> 10000 nM
Compound: 27f
Antiproliferative activity against human MRC5 cells after 72 hrs by WST8 assay
Antiproliferative activity against human MRC5 cells after 72 hrs by WST8 assay
[PMID: 25625617]
NCI-H358 IC50
320 nM
Compound: 27f
Antiproliferative activity against human NCI-H358 cells after 72 hrs by WST8 assay
Antiproliferative activity against human NCI-H358 cells after 72 hrs by WST8 assay
[PMID: 25625617]
NCI-H460 IC50
10 nM
Compound: 27f
Antiproliferative activity against human NCI-H460 cells after 72 hrs by WST8 assay
Antiproliferative activity against human NCI-H460 cells after 72 hrs by WST8 assay
[PMID: 25625617]
PC-14 IC50
9.8 nM
Compound: 27f
Antiproliferative activity against human PC14 cells after 72 hrs by WST8 assay
Antiproliferative activity against human PC14 cells after 72 hrs by WST8 assay
[PMID: 25625617]
分子量

516.56

Formula

C26H31F3N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mps1-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mps1-IN-41263423-94-4Mps1Monopolar spindle 1Inhibitorinhibitorinhibit

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