2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. MPT0B002

MPT0B002 是一种具有抗癌活性的强效微管 (microtubule) 抑制剂。MPT0B002 可破坏微管蛋白聚合、诱导细胞凋亡 (apoptosis)，并将细胞周期停滞在 G2/M 期。

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MPT0B002 Chemical Structure

MPT0B002 Chemical Structure

CAS No. : 946077-08-3

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MPT0B002 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MPT0B002 is a potent microtubule inhibitor with anticancer activities. MPT0B002 disrupts tubulin polymerization, induces apoptosis, and arrests cell cycle at the G2/M phase[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.12 μM
Compound: XIII
Cytotoxicity against human A549 cells after 72 hrs by XTT assay
Cytotoxicity against human A549 cells after 72 hrs by XTT assay
[PMID: 19939521]
A549 IC50
0.12 μM
Compound: 4d
Cytotoxicity against human A549 cells after 72 hrs by XTT assay
Cytotoxicity against human A549 cells after 72 hrs by XTT assay
[PMID: 19647439]
A549 IC50
0.12 μM
Compound: 7
Cytotoxicity against human A549 cells after 72 hrs by XTT method
Cytotoxicity against human A549 cells after 72 hrs by XTT method
[PMID: 18502133]
A549 IC50
190 nM
Compound: 4
Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by XTT assay
Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by XTT assay
[PMID: 23470139]
HeLa IC50
0.034 μM
Compound: XIII
Cytotoxicity against human HeLa cells after 72 hrs by XTT assay
Cytotoxicity against human HeLa cells after 72 hrs by XTT assay
[PMID: 19939521]
HeLa IC50
0.034 μM
Compound: 7
Cytotoxicity against human HeLa cells after 72 hrs by XTT method
Cytotoxicity against human HeLa cells after 72 hrs by XTT method
[PMID: 18502133]
HeLa IC50
0.035 μM
Compound: 4d
Cytotoxicity against human HeLa cells after 72 hrs by XTT assay
Cytotoxicity against human HeLa cells after 72 hrs by XTT assay
[PMID: 19647439]
HeLa IC50
25 nM
Compound: 4
Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by XTT assay
Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by XTT assay
[PMID: 23470139]
HL-60 IC50
27 nM
Compound: 4
Cytotoxicity against human HL60 cells assessed as growth inhibition after 72 hrs by XTT assay
Cytotoxicity against human HL60 cells assessed as growth inhibition after 72 hrs by XTT assay
[PMID: 23470139]
HT-29 IC50
10.5 nM
Compound: 14
Growth inhibition of human HT29 cells after 72 hrs by methylene blue dye assay
Growth inhibition of human HT29 cells after 72 hrs by methylene blue dye assay
[PMID: 17685504]
HT-29 IC50
27 nM
Compound: 4
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by XTT assay
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by XTT assay
[PMID: 23470139]
KB IC50
13.6 nM
Compound: 14
Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay
Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay
[PMID: 17685504]
MKN-45 IC50
11.2 nM
Compound: 14
Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay
Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay
[PMID: 17685504]
NCI-H460 IC50
14.1 nM
Compound: 14
Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay
Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay
[PMID: 17685504]
TSGH IC50
13.4 nM
Compound: 14
Growth inhibition of human TSGH cells after 72 hrs by methylene blue dye assay
Growth inhibition of human TSGH cells after 72 hrs by methylene blue dye assay
[PMID: 17685504]
体外研究
(In Vitro)

MPT0B002 (1-1000 nM；48 小时) 可诱导 G2/M 期细胞周期停滞[1]。
MPT0B002 (100 nM；24 小时) 以剂量依赖性方式抑制 K562、BaF3/p210 和 BaF3/T315I 细胞中的细胞活力[1]。
MPT0B002 (100 nM; 48 h) 诱导细胞凋亡，并可下调 Bcr-Abl 和 Bcr-Abl-T315I mRNA 表达和蛋白质水平以及下游信号通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MPT0B002 相关抗体:

Cell Viability Assay[1]

Cell Line: K562, BaF3/p210, and BaF3/T315I cells
Concentration: 1 nM, 10 nM, 100 nM, 1000 nM
Incubation Time: 48 h
Result: Inhibited cell viability in a dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: K562, BaF3/p210, and BaF3/T315I cells
Concentration: 100 nM
Incubation Time: 24 h
Result: Induced G2/M-phase cell cycle arrest.

Apoptosis Analysis[1]

Cell Line: K562, BaF3/p210, and BaF3/T315I cells
Concentration: 100 nM
Incubation Time: 48 h
Result: Induced apoptosis and caspase-3 pathway.

Western Blot Analysis[1]

Cell Line: K562, BaF3/p210, and BaF3/T315I cells
Concentration: 100 nM
Incubation Time: 48 h
Result: Significantly reduced the expression level of Bcr-Abl, and reduced the phosphorylations of Crkl and Stat5.
分子量

325.36

Formula

C19H19NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MPT0B002 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MPT0B002946077-08-3Microtubule/TubulinApoptosismicrotubule inhibitoranticancer activitiestubulin polymerizationinduces apoptosisInhibitorinhibitorinhibit

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目录号：
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