2. Epigenetics
  3. Epigenetic Reader Domain
  4. MS31

MS31 是一种高亲和性，高选择性，片段样的甲基赖氨酸读写蛋白 spindlin 1 (SPIN1) 抑制剂，有效破坏 SPIN1 与 H3K4me3 蛋白互相作用 (IC50=77 nM，AlphaLISA；243 nM，FP). MS31 选择性结合 SPIN1 的 Tudor 结构域 II (Kd=91 nM)。MS31 能有效抑制含三甲基赖氨酸肽与 SPIN1 的结合，对非肿瘤性细胞无毒。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 MS31 trihydrochloride 通常具有更好的水溶性和稳定性。

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MS31 Chemical Structure

MS31 Chemical Structure

CAS No. : 2366264-12-0

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规格 价格 是否有货
1 mg ￥2045
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5 mg ￥4500
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10 mg 现货 询问价格 & 货期

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MS31 的其他形式现货产品:

Customer Review

Other Forms of MS31:

MS31 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MS31 is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1. MS31 is not toxic to nontumorigenic cells[1].

IC50 & Target

IC50: 77 nM (SPIN1 by AlphaLISA), 243 nM (SPIN1 by FP)[1]
Kd: 91 nM (SPIN1)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
U2OS IC50
3.2 μM
Compound: 3; MS31
Inhibition of C-terminal Halo Tag-histone H3.3/N-terminal Nano Luciferase-fused full length SPIN1 (unknown origin) transfected in human U2OS cells assessed as reduction in SPIN1 and histone H3 interaction incubated for 24 hrs by NanoBRET assay
Inhibition of C-terminal Halo Tag-histone H3.3/N-terminal Nano Luciferase-fused full length SPIN1 (unknown origin) transfected in human U2OS cells assessed as reduction in SPIN1 and histone H3 interaction incubated for 24 hrs by NanoBRET assay
[PMID: 31260300]
体外研究
(In Vitro)

MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1, displays high binding affinity, is highly selective for SPIN1 over other epigenetic readers and writers, directly engages SPIN1 in cells, and is not toxic to nontumorigenic cells. MS31 selectively binds tudor domain II of SPIN1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MS31 相关抗体:
分子量

341.45

Formula

C20H27N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MS31 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS312366264-12-0MS 31MS-31Epigenetic Reader Domainmethyllysinereaderproteintudordomainprotein-proteininteractionsH3K4me3Inhibitorinhibitorinhibit

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