2. MAPK/ERK Pathway
  3. MAP3K p38 MAPK
  4. MSC 2032964A

MSC 2032964A 是一种具有选择性的，口服有效的凋亡信号调节激酶 1 (ASK1) 抑制剂，IC50 为 96 nM。MSC 2032964A 在 EAE 小鼠模型中保留了小鼠的视觉反应，具有改善神经炎症的作用。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

MSC 2032964A Chemical Structure

MSC 2032964A Chemical Structure

CAS No. : 1124381-43-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

MSC 2032964A 相关抗体

Top Publications Citing Use of Products

查看 MAP3K 亚型特异性产品:

查看所有亚型
MAP3K7/TAK1 MAP3K8 ASK2 MAP3K5/ASK1

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MSC 2032964A is an orally active, selective inhibitor for apoptosis signal-regulating kinase 1(ASK1) with IC50 of 96 nM. MSC 2032964A preserves the visual responses in EAE mice model and exhibits potency in ameliorating the neuroinflammation[1].

IC50 & Target

ASK1

96 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK-293T IC50
13 nM
Compound: 3; MSC2032964A
Inhibition of V5 tagged human ASK1 expressed in HEK-293T cells assessed as reduction in T838 autophosphorylation incubated for 1 hr
Inhibition of V5 tagged human ASK1 expressed in HEK-293T cells assessed as reduction in T838 autophosphorylation incubated for 1 hr
[PMID: 31710475]
体外研究
(In Vitro)

MSC 2032964A (10 μM) 显示出良好的代谢稳定性，微粒体清除率 <4 ml/min/mg，以及良好的表观通透性[1]。
MSC 2032964A (10 μM) 抑制 Lipopolysaccharide (LPS, HY-D1056) 诱导的小鼠星形胶质细胞中 ASK1 和 p38 磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MSC 2032964A 相关抗体:

Western Blot Analysis[1]

Cell Line: mouse astrocytes
Concentration: 10 μM
Incubation Time: 90 min
Result: Inhibited phosphorylation of ASK1 and p38.
体内研究
(In Vivo)

MSC 2032964A (5 mg/kg，口服) 在 SD 大鼠中的口服生物利用度为 82%，清除率为 1.1 L/kg/h，半衰期为 5.2 小时，分布容积 Vss 1.0 L/kg[1]。
MSC 2032964A (30 mg/kg，口服，每天一次共 40 天) 可减轻脊髓和视神经病变产生的神经症状，从而改善 C57BL/6J 小鼠模型中由 MOG (35-55) (HY-P1240) 诱导的自身免疫性脑脊髓炎[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MOG (35-55)-induced autoimmune encephalomyelitis in C57BL/6J mice[1]
Dosage: 30 mg/kg
Administration: p.o., once daily for 40 days
Result: Reduced demyelination in optic nerve, decreased astrocyte and microglia activation in spinal cord.
分子量

362.31

Formula

C16H13F3N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MSC 2032964A 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MSC 2032964A1124381-43-6MAP3Kp38 MAPKMAP kinase kinase kinase, MEKK, MAPKKKmultiple sclerosisencephalomyelitisInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
MSC 2032964A
目录号：
HY-110262
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z