2. Cell Cycle/DNA Damage Others
  3. Topoisomerase Others
  4. MSN8C

MSN8C 是曼索酮 E 的类似物，是一种新型人类 DNA 拓扑异构酶 II 催化抑制剂。MSN8C 诱导癌细胞凋亡。MSN8C 在体外表现出显着的抗肿瘤细胞增殖活性。

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MSN8C Chemical Structure

MSN8C Chemical Structure

CAS No. : 1314798-31-6

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MSN8C 相关抗体

Top Publications Citing Use of Products

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MSN8C, an analog of mansonone E, is a novel catalytic inhibitor of human DNA topoisomerase II. MSN8C induces cancer cell apoptosis. MSN8C shows significant anti-tumor cell proliferation activity in vitro[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CNE-2 IC50
2.05 μM
Compound: 7
Antitumor against human CNE2 cells assessed as cell survival after 48 hrs by MTT assay
Antitumor against human CNE2 cells assessed as cell survival after 48 hrs by MTT assay
[PMID: 21600681]
体外研究
(In Vitro)

MSN8C 防止超螺旋 DNA 进入催化循环，以避免被 Topo II 毒物捕获并减少 DNA 碎片的产生[1]。
MSN8C (1-10 μM, 24 h) 通过以剂量依赖性方式增加 caspase-3 表达来诱导凋亡[1]。
MSN8C (1、5、10、20 μM，12 小时) 增加 HL-60 细胞中的 caspase-8 和 caspase-9 活性[1]。
MSN8C (48 h) 可抑制 11 种不同来源的人类肿瘤细胞系，平均 IC50 值为 2.60 µM[1]。
MSN8C 对人乳腺癌阿霉素耐药细胞系 MCF-7/Adr 和米托蒽醌耐药细胞系 HL-60/MX2 具有很强的抗增殖作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MSN8C 相关抗体:

Western Blot Analysis[1]

Cell Line: HL-60 cells
Concentration: 10 μM
Incubation Time: 1 h
Result: Reduced γ-H2AX expression levels.
Weakened the production of γ-H2AX by VP-16.

Western Blot Analysis[1]

Cell Line: HL-60 cells
Concentration: 1, 5, 10, 20 μM
Incubation Time: 1, 5, 10, 20 μM
Result: Induced caspases-3 express in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: HL-60 cells
Concentration: 5, 10 μM
Incubation Time: 12 h
Result: Promoted caspase-8 and caspase-9 activity in a dose-dependent manner.
体内研究
(In Vivo)

MSN8C（10 mg/kg，腹腔注射，两天间隔，持续 2 周）在 A549 肿瘤异种移植模型中抑制肿瘤生长，且毒性更低[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A549 tumor xenograft model, female BALB/c nude mice[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.), two-day intervals for 2 weeks
Result: Inhibits tumor with the tumor weight inhibition (TWI) value of 74.2%.
分子量

214.22

Formula

C13H10O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MSN8C 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MSN8C1314798-31-6TopoisomeraseOthersHuman DNA topoisomerase II Inhibitoranti-tumorA549 tumor xenograft modelInhibitorinhibitorinhibit

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产品名称：
MSN8C
目录号：
HY-149410
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