Muscimol hydrochloride  (Synonyms: 蝇蕈醇盐酸盐; Agarin hydrochloride; Agarine hydrochloride)

Muscimol (Agarin; Agarine) hydrochloride is an isoxazole with psychoactive activity. Muscimol hydrochloride is also a selective agonist of the inhibitory neurotransmitter, GABA ionotropic receptors. Muscimol hydrochloride can be isolated from from Amanita muscaria and related mushrooms. All in all, Muscimol is a potent GABA_A receptors agonist (EC₅₀=0.2 μM), a partial GABA_Creceptors agonist, and an inactive GABA_B receptors agonist. Muscimol hydrochloride has calming, anti-anxiety and hallucinatory effects^[1].

EC50: 0.2 μM (GABA_Creceptors)^[1]

Muscimol 影响前额叶皮层的功能，并且在注射到腹侧前额叶皮层后（1μL，5μg/μL；前额叶皮层输注），损害猴子在计数任务中的表现，但在注射到背侧前额叶皮层后没有影响^[2]。
Muscimol 影响前扣带皮层 (ACC) 的微量调节，并且在 10 秒微量组中（62.5 或 125 µg/侧）对抑制噪声刺激没有影响^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

150.56

C₄H₇ClN₂O₂

3579-03-1

固体

White to light yellow

蝇蕈醇盐酸盐；毒蕈胺盐酸盐

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Johnston GA. Muscimol as an ionotropic GABA receptor agonist. Neurochem Res. 2014 Oct;39(10):1942-7.  [Content Brief]

  [2]. Sun W, et al. Muscimol-induced inactivation of the ventral prefrontal cortex impairs counting performance in rhesus monkeys. Sci Prog. 2022 Oct-Dec;105(4):368504221141660.  [Content Brief]

  [3]. Pezze MA, et al. Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat. J Psychopharmacol. 2020 Dec;34(12):1457-1460.  [Content Brief]