Mycro1 

Mycro1 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC₅₀ value of 30 μM for the inhibition of Myc/Max DNA binding activity. Mycro1 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation^[1].

Mycro1(10 or 20 μM, 7 days)可以抑制 C-Myc 依赖细胞系 U-2OS、MCF-7、Raji 和 NIH/3T3 的增殖，不会抑制 C-Myc 独立癌细胞株 PC-12 的增殖。Mycro1 在 10 μM 时可以显著抑制 c- myc 诱导的基因转录，在 20 μM 时可以选择性减少 c- myc 转化Rat1a细胞的非锚定生长^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

432.42

C₂₀H₁₅F₃N₄O₂S

313987-85-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kiessling A, et al. Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules. Chem Biol. 2006 Jul;13(7):745-51.  [Content Brief]

  [2]. Anke Kiessling, et al. Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules. Chem Biol. 2006 Jul;13(7):745-51.