2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. Myrtucommulone A

Myrtucommulone A 是一种非异戊烯基化的酰基间苯三酚，可从 Myrtus communis (myrtle) 中分离出来。Myrtucommulone A 与 HSP60 伴侣蛋白相互作用并抑制 HSP60 伴侣蛋白活性。Myrtucommulone A 可降低 LRP130, LONP 的表达。

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Myrtucommulone A Chemical Structure

Myrtucommulone A Chemical Structure

CAS No. : 54247-21-1

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Myrtucommulone A 相关抗体

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Myrtucommulone A is a non-prenylated acylphloroglucinol that can be isolated from Myrtus communis (myrtle). Myrtucommulone A interacts with the HSP60 chaperone and inhibits HSP60 chaperone activity. Myrtucommulone A decreases the expression of LRP130, LONP[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
1 μM
Compound: 1, myrtucommulone A, MC A
Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 formation preincubated for 15 mins followed by substrate addition measured after 1 min by RP-HPLC analysis
Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 formation preincubated for 15 mins followed by substrate addition measured after 1 min by RP-HPLC analysis
[PMID: 26123643]
DU-145 IC50
5 μM
Compound: 4
Cytotoxicity against human DU145 cells after 96 hrs
Cytotoxicity against human DU145 cells after 96 hrs
[PMID: 22276775]
HepG2 IC50
6 μM
Compound: 4
Cytotoxicity against human HepG2 cells after 96 hrs
Cytotoxicity against human HepG2 cells after 96 hrs
[PMID: 22276775]
Jurkat EC50
2.4 μM
Compound: 1, myrtucommulone A, MC A
Cytotoxicity against human Jurkat cells assessed as induction of cell death after 48 hrs by MTT assay
Cytotoxicity against human Jurkat cells assessed as induction of cell death after 48 hrs by MTT assay
[PMID: 26123643]
MT4 IC50
4.7 μM
Compound: 4
Cytotoxicity against human MT4 cells after 96 hrs
Cytotoxicity against human MT4 cells after 96 hrs
[PMID: 22276775]
体外研究
(In Vitro)

Myrtucommulone A (0, 10, 30 µM) 在 37 ℃ 和 42 ℃ 时降低 LRP130 和 LONP 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Myrtucommulone A 相关抗体:
分子量

668.81

Formula

C38H52O10
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Myrtucommulone A 相关分类

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Keywords:

Myrtucommulone A54247-21-1HSPHeat shock proteinsHSP60 chaperoneLRP130LONPInhibitorinhibitorinhibit

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