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  4. N2-Methyl-L-arginine

N2-Methyl-L-arginine 是一种选择性 L-arginine 摄取抑制剂，其 Ki 值为 500 μM。

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N2-Methyl-L-arginine Chemical Structure

N2-Methyl-L-arginine Chemical Structure

CAS No. : 2480-28-6

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规格 价格 是否有货 数量
5 mg ￥2809
3 - 4 周
10 mg ￥4493
3 - 4 周
50 mg   询价  
100 mg   询价  

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N2-Methyl-L-arginine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

N2-Methyl-L-arginine is a selective L-arginine uptake inhibitor, with a Ki value of 500 μM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Macrophage IC50
28 μM
Compound: L-NMMA
Inhibition of LPS-induced NO production in ddY mouse peritoneal macrophages by Griess reagent method
Inhibition of LPS-induced NO production in ddY mouse peritoneal macrophages by Griess reagent method
[PMID: 12542351]
Macrophage IC50
64.24 μM
Compound: L-NMMA
Inhibition of LPS-stimulated nitric oxide production in BALB/c mouse macrophages after 20 hrs by Griess assay relative to control
Inhibition of LPS-stimulated nitric oxide production in BALB/c mouse macrophages after 20 hrs by Griess assay relative to control
[PMID: 18723353]
Peritoneal macrophage cell IC50
36 μM
Compound: L-NMMA
Hepatoprotective activity in ddY mouse peritoneal macrophages assessed as inhibition of LPS-induced nitric oxide production after 20 hrs by Griess method relative to untreated control
Hepatoprotective activity in ddY mouse peritoneal macrophages assessed as inhibition of LPS-induced nitric oxide production after 20 hrs by Griess method relative to untreated control
[PMID: 19775895]
RAW264.7 IC50
39.2 μM
Compound: N-monomethyl-L-arginine
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess assay
[PMID: 24547740]
Sf9 IC50
0.65 μM
Compound: L-NMMA
Inhibition of human eNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubated for 15 mins with compound measured after 45 mins by scintillation counting
Inhibition of human eNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubated for 15 mins with compound measured after 45 mins by scintillation counting
[PMID: 22420844]
Sf9 IC50
0.95 μM
Compound: L-NMMA
Inhibition of human nNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubated for 15 mins with compound measured after 45 mins by scintillation counting
Inhibition of human nNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubated for 15 mins with compound measured after 45 mins by scintillation counting
[PMID: 22420844]
Sf9 IC50
1.8 μM
Compound: L-NMMA
Inhibition of human iNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubated for 15 mins with compound measured after 45 mins by scintillation counting
Inhibition of human iNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubated for 15 mins with compound measured after 45 mins by scintillation counting
[PMID: 22420844]
分子量

188.23

Formula

C7H16N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

N2-Methyl-L-arginine 相关分类

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  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N2-Methyl-L-arginine2480-28-6Biochemical Assay ReagentsL-arginineInhibitorinhibitorinhibit

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