2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. NADH disodium hydrate

NADH disodium hydrate  (Synonyms: Disodium NADH hydrate)

目录号: HY-F0001A
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摩尔计算器

NADH disodium salt (Disodium NADH) hydrate 是一种口服有效的还原型辅酶。NADH disodium salt hydrate 还是 ADP-核糖基转移酶反应中的 ADP-核糖单元的供体和环状 ADP-核糖的前体。NADH disodium salt hydrate 在细胞的能量代谢过程中起到再生电子供体的作用，包括糖酵解，β-氧化和三羧酸 (TCA) 循环。

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NADH disodium hydrate Chemical Structure

NADH disodium hydrate Chemical Structure

CAS No. : 1949720-50-6

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NADH disodium hydrate 的其他形式现货产品:

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NADH disodium hydrate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NADH disodium salt (Disodium NADH) hydrate is an orally active reduced coenzyme. NADH disodium salt hydrate is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt hydrate plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle[1].

体外研究
(In Vitro)

NADH is unstable under acidic conditions but it is stable under alkaline conditions[2].
NADH (0-1 mM; 0-12 h) increases NAD+ levels in various mammalian cell lines[3].
NADH (1 mM; 24 h) causes low toxicity and protects cells from genotoxicity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NADH disodium hydrate 相关抗体:
体内研究
(In Vivo)

NADH (5 μmol/mouse; i.p.; once) increases urinary excretion of nicotinamide and its metabolites in mice[2].
NADH (500 mg/kg; i.g.; once) promotes alcohol metabolism and prevents or ameliorates early liver injury caused by acute alcohol exposure in ethanol-loaded mice[3].
NADH (1000 mg/kg; i.p.; once) enhances tissue NAD+ levels in male C57BL/6J mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice[2]
Dosage: 5 μmol/mouse
Administration: Intraperitoneal injection or oral administration, once
Result: Produced significant increases in urinary excretions of nicotinamide (Nam) with intraperitoneal injection. Oral administration did not produce any increases in Nam or its metabolites.
Animal Model: Male C57BL/6J mice[3]
Dosage: 500 mg/kg
Administration: Intragastric administration, 15 min before ethanol administration
Result: Significantly increased blood acetaldehyde levels in mice administered with alcohol between 30 min and two hours. Significantly reduced the acetaldehyde in the blood after two hours. Inhibited the decrease of NAD+/NADH redox ratio in hepatocytes.
Formula

C21H29N7O14P2.xH2O.2Na
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NADH disodium hydrate 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NADH disodium1949720-50-6Disodium NADHEndogenous Metaboliteorally activereduced coenzymeglycolysisβ-oxidationTCAInhibitorinhibitorinhibit

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