2. Epigenetics
  3. Histone Demethylase
  4. Namoline

Namoline  (Synonyms: 萘莫胺)

目录号: HY-115747
产品使用指南

摩尔计算器

Namoline，一种 γ-pyrone，是选择性、可逆的赖氨酸特异性脱甲基酶 1 (LSD1) 抑制剂，在 HRP 偶联酶测定中的 IC50 为 51 μM。Namoline 损害 LSD1 去甲基化酶活性并阻止细胞增殖。Namoline 具有雄激素依赖性前列腺癌研究的潜力。

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Namoline Chemical Structure

Namoline Chemical Structure

CAS No. : 342795-11-3

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Namoline 相关抗体

Top Publications Citing Use of Products

查看 Histone Demethylase 亚型特异性产品:

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KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Namoline, a γ-pyrone, is a selective and reversible Lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 51 μM in a HRP-coupled enzymatic assay. Namoline impairs LSD1 demethylase activity and blocks cell proliferation. Namoline has the potential for androgen-dependent prostate cancer research[1].

体外研究
(In Vitro)

Namoline (50 μM; 24, 48, 72 hours) reduces androgen-induced proliferation of LNCaP cells[1].
Namoline (50 μM) specifically impairs AR agonist R1881-induced (1 nM) demethylation of H3K9me1 and H3K9me2 in LNCaP cells[1].
Namoline (50 μM) does not affect the enzymatic activities of MAOs under these conditions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Namoline 相关抗体:
体内研究
(In Vivo)

Namoline (0.02 mg;ip; daily) severely blunts xenograft tumor growth in nude mice with LNCaP cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

293.58

Formula

C10H3ClF3NO4
CAS 号
中文名称

萘莫胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Namoline 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Namoline342795-11-3萘莫胺Histone Demethylaseγ-pyroneLysine-specific demethylase 1LSD1prostate cancerH3K9me1H3K9me2LNCaP cellInhibitorinhibitorinhibit

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