2. Metabolic Enzyme/Protease
  3. NAMPT
  4. Nampt-IN-7

Nampt-IN-7 (compound GF8) 是一种有效的 NAMPT 抑制剂，其 IC50 为 7.31 μM。Nampt-IN-7 对人 HepG2 肝癌细胞系具有细胞毒性活性，其 IC50 值为 24.28 μM。

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Nampt-IN-7 Chemical Structure

Nampt-IN-7 Chemical Structure

CAS No. : 1223378-42-4

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Nampt-IN-7 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nampt-IN-7 (compound GF8) is a potent NAMPT inhibitor, with an IC50 of 7.31 μM. Nampt-IN-7 also displays cytotoxic activity against human HepG2 hepatocellular carcinoma cell line with an IC50 of 24.28 μM[1].

IC50 & Target

IC50: 7.31 ± 1.59 μM (NAMPT)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 IC50
24.28 μM
Compound: GF8
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay
[PMID: 31818629]
分子量

379.41

Formula

C20H21N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nampt-IN-7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nampt-IN-71223378-42-4NAMPTNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorPharmacophore modelingVirtual screeningHepG2hepatocellular carcinomaInhibitorinhibitorinhibit

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