2. Cytoskeleton
  3. Integrin
  4. Natalizumab

Natalizumab  (Synonyms: 那他珠单抗)

目录号: HY-108831 纯度: 99.10%
COA 技术支持

Natalizumab 是一种重组的人源化 IgG4 单克隆抗体，与 α4β1-整联蛋白 (α4β1-integrin) 结合并阻断其与血管细胞粘附分子 1 (VCAM-1) 的相互作用。Natalizumab 可用于复发缓解型多发性硬化症和克罗恩氏病的研究。Natalizumab 也可阻止淋巴细胞进入中枢神经系统，从而防止急性脱髓鞘复发。

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CAS No. : 189261-10-7

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规格 价格 是否有货 数量
1 mg ￥1600
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5 mg ￥4200
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10 mg ￥6700
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Customer Review

Other Forms of Natalizumab:

Natalizumab 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 2 篇科研文献

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Natalizumab is a recombinant, humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses[1].

同型

Human IgG4 kappa
推荐同型对照抗体
种属

Humanized
IC50 & Target

α4β1

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
> 10000 nM
Compound: Senktide
Displacement of [125I]-BH-SP from NK1 receptor (unknown origin) expressed in CHO cells by scintillation counter
Displacement of [125I]-BH-SP from NK1 receptor (unknown origin) expressed in CHO cells by scintillation counter
10.1039/C4MD00514G
CHO IC50
> 10000 nM
Compound: Senktide
Displacement of [125I]-NKA from NK2 receptor (unknown origin) expressed in CHO cells by scintillation counter
Displacement of [125I]-NKA from NK2 receptor (unknown origin) expressed in CHO cells by scintillation counter
10.1039/C4MD00514G
CHO IC50
0.056 μM
Compound: Senktide
Displacement of [125I]His3, MePhe7 from human NK3R expressed in CHO cell membranes by scintillation counting
Displacement of [125I]His3, MePhe7 from human NK3R expressed in CHO cell membranes by scintillation counting
[PMID: 25247671]
CHO IC50
21 nM
Compound: Senktide
Binding affinity towards human Tachykinin receptor 3 stably expressed in CHO cells using [125I][MePhe7]-NKB as radioligand
Binding affinity towards human Tachykinin receptor 3 stably expressed in CHO cells using [125I][MePhe7]-NKB as radioligand
10.1016/0960-894X(95)00313-I
CHO IC50
29 nM
Compound: Senktide
Displacement of ([125I]His3-MePhe7)-NKB from NK3 receptor (unknown origin) expressed in CHO cells by scintillation counter
Displacement of ([125I]His3-MePhe7)-NKB from NK3 receptor (unknown origin) expressed in CHO cells by scintillation counter
10.1039/C4MD00514G
CHO EC50
7 nM
Compound: Senktide
Compound was evaluated for concentration-dependent and oscillatory increase in [Ca2+], caused by activation of hNK3 receptors in CHO cells
Compound was evaluated for concentration-dependent and oscillatory increase in [Ca2+], caused by activation of hNK3 receptors in CHO cells
[PMID: 9871763]
体外研究
(In Vitro)

Natalizumab 是一种重组人源化抗体，可与 α4β1-整合素结合并阻断其与 VCAM-1 的相互作用。结果，白细胞向脑组织的迁移受到抑制，从而减少炎症并防止病变的形成。Natalizumab 还可以通过中断表达 α4 整合素的白细胞与细胞外基质蛋白 (如纤连蛋白和骨桥蛋白) 之间的相互作用来抑制由已存在于 CNS 中的白细胞介导的持续中枢神经系统 (CNS) 炎症[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Natalizumab 相关抗体:
体内研究
(In Vivo)

可快速结合 α4-整合素并具有高亲和力。在静脉内 (IV) 剂量的那他珠单抗 1 mg/kg 至 6 mg/kg 后 24 小时，在分离的淋巴细胞膜上体外测量的最大结合（饱和度≥80%）[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

那他珠单抗
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
纯度 & 产品资料

纯度: 99.10%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Natalizumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Natalizumab189261-10-7那他珠单抗IntegrinInhibitorinhibitorinhibit

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目录号：
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