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  4. NC1153

NC1153是一种Mannich碱，具有阻止IL-2诱导的JAK3激活及其下游底物STAT5a/b的活性。NC1153有效延长MHC/non-MHC不匹配大鼠肾脏移植的存活时间。NC1153促进了移植物的长期存活，并包括对受体的多重毒性保护。NC1153与环孢素A（CsA）联用可以协同延长移植物存活而不产生肾毒性、骨髓毒性或脂毒性。

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NC1153 Chemical Structure

NC1153 Chemical Structure

CAS No. : 150661-91-9

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NC1153 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NC1153 is a Mannich base with the activity to block IL-2-induced JAK3 activation and its downstream substrate STAT5a/b. NC1153 effectively prolongs the survival of kidney transplants in MHC/non-MHC mismatched rats. NC1153 promotes long-term graft survival and includes multiple toxicity protection for recipients. NC1153 combined with cyclosporine A (CsA) can synergistically prolong graft survival without producing nephrotoxicity, myelotoxicity or lipotoxicity[1].

分子量

369.41

Formula

C18H38Cl2N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NC1153 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NC1153150661-91-9NC 1153NC-1153OthersInhibitorinhibitorinhibit

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