2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Nebivolol

Nebivolol  (Synonyms: 奈必洛尔; R 065824)

目录号: HY-B0203
产品使用指南

摩尔计算器

Nebivolol (R 065824) 是一种 β 受体阻滞剂，具有口服活性和高 β (1)-受体亲和力。Nebivolol 具有直接的血管扩张剂特性和肾上腺素能阻断特性。Nebivolol 可用于高血压、冠状动脉疾病、充血性心力衰竭和缺血性心脏病等多种疾病的研究。

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Nebivolol Chemical Structure

Nebivolol Chemical Structure

CAS No. : 118457-14-0

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规格 价格 是否有货 数量
5 mg ￥850
1 - 2 周
10 mg ￥1360
1 - 2 周
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Nebivolol 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nebivolol (R 065824) is an orally active beta receptor blocker and has the high beta(1)-receptor affinity. Nebivolol has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease[1][2].

体外研究
(In Vitro)

Nebivolol improves endothelial dysfunction via its strong stimulatory effects on the activity of the endothelial nitric oxide synthase and via its antioxidative properties[1].
Nebivolol (0.1 μM-10 μM, 1, 2, 4, 7 or 14 days) inhibits haCSMC or haEC proliferation with IC50 values of ~ 6.0 μM[2].
Nebivolol (0.1 μM-10 μM, 24 h) induces a moderate rate of apoptosis[2].
Nebivolol (0.1, 1, 5,10 μM, 4 days)increases NO formation and decreases endothelin-1 secretion in HaCEs[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nebivolol 相关抗体:

Cell Proliferation Assay[2]

Cell Line: haCSMCs (human coronary smooth muscle cells) and haECs (endothelial cells)
Concentration: 0.1 μM-10 μM
Incubation Time: 1, 2, 4, 7 or 14 days
Result: Reduced proliferation in HaECs and HaCSMCs in a concentration- and time-dependent.

Apoptosis Analysis[2]

Cell Line: haCSMCs and haECs
Concentration: 0.1 μM-10 μM
Incubation Time: 24 h
Result: Induced a moderate apoptosis in concentration-dependent and showed a decrease of haCSMCs in the S-phase by 66%.
Clinical Trial
分子量

405.44

Formula

C22H25F2NO4
CAS 号
中文名称

奈必洛尔
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nebivolol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nebivolol118457-14-0R 065824奈必洛尔R065824R-065824Adrenergic ReceptorBeta Receptororalbeta receptorvasodilatoradrenergic blockinghypertensioncoronary artery diseasecongestive heart failureischemic heart diseaseInhibitorinhibitorinhibit

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