2. Anti-infection
  3. Bacterial
  4. Neoaureothin

Neoaureothin  (Synonyms: NSC 260179; Spectinabilin)

目录号: HY-N8504
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Neoaureothin 是一种细菌代谢物，存在于链霉菌中。它是一种雄激素受体 (AR) 拮抗剂，可抑制双氢睾酮 (DHT) 与 AR 的结合 (IC50=13 μM)，并抑制 LNCaP 细胞中 DHT 诱导的前列腺特异性抗原表达 (IC50=1.75 nM)。Neoaureothin 对 A549、HCT116 和 HepG2 细胞具有细胞毒性 (IC50s 分别为 34.3、47 和 37.2 μg/mL)。它还具有针对松木线虫 B. xylophilus 的杀线虫活性 (LC50=0.84 μg/mL)，并可提高接种 B. xylophilus 的 P. densiflora 树的存活率。

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Neoaureothin Chemical Structure

Neoaureothin Chemical Structure

CAS No. : 59795-94-7

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Neoaureothin 相关抗体

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  • 生物活性

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生物活性

Neoaureothin is a bacterial metabolite that has been found in Streptomyces. It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs (IC50=13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50=1.75 nM). Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells (IC50s=34.3, 47, and 37.2 μg/mL, respectively). It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50=0.84 μg/mL) and increases survival of P. densiflora trees inoculated with B. xylophilus.

分子量

477.55

Formula

C28H31NO6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Neoaureothin 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neoaureothin59795-94-7NSC 260179 SpectinabilinNSC260179NSC-260179BacterialInhibitorinhibitorinhibit

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