2. Cytoskeleton
  3. Integrin
  4. Nesvategrast

Nesvategrast  (Synonyms: SF0166)

目录号: HY-117133
产品使用指南

摩尔计算器

Nesvategrast (SF0166) 是一种有效的选择性 αvβ3 拮抗剂，对于 αvβ3，αvβ6，和 αvβ8 的 IC50 值分别为 0.6 nM, 8 nM 和 13 nM。Nesvategrast 抑制人、大鼠、兔和狗细胞系中玻连蛋白的细胞粘附，IC50 值为 7.6 pM 至 76 nM。Nesvategrast 在氧诱导视网膜病变小鼠模型中减少新生血管。

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Nesvategrast Chemical Structure

Nesvategrast Chemical Structure

CAS No. : 1621332-91-9

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Nesvategrast 相关抗体

Top Publications Citing Use of Products

查看 Integrin 亚型特异性产品:

查看所有亚型
αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nesvategrast (SF0166) is a potent and selective αvβ3 antagonist with IC50 values of 0.6 nM, 8 nM, and 13 nM for αvβ3, αvβ6, and αvβ8, respectively. Nesvategrast inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 values of 7.6 pM to 76 nM. Nesvategrast decreases neovascularization in the oxygen-induced retinopathy mouse model[1].

IC50 & Target[1]

αvβ3

0.6 nM (IC50)

αvβ6

8 nM (IC50)

αvβ8

13 nM (IC50)

体外研究
(In Vitro)

Nesvategrast (0.5-4 μg; 12天; 鸡胚绒毛尿囊膜 (CAM) 模型) 以剂量依赖的方式抑制碱性成纤维细胞生长因子刺激的血管生成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nesvategrast 相关抗体:
体内研究
(In Vivo)

Nesvategrast (双侧眼局部滴注 5% Nesvategrast) 抑制 129SVE 新生小鼠氧诱导视网膜病变 (OIR) 模型视网膜新生血管[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female 129SVE newborn mice with oxygen-induced retinopathy (OIR) models[1]
Dosage: 5% SF0166
Administration: Bilateral eye topical drip 5% SF0166
Result: Reduced new blood vessel formation.
Clinical Trial
分子量

475.49

Formula

C23H27F2N5O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nesvategrast 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nesvategrast1621332-91-9SF0166SF 0166SF-0166Integrincellular adhesionvitronectinchick chorioallantoic membraneneovascularizationInhibitorinhibitorinhibit

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