Neuraminidase-IN-11 

Neuraminidase-IN-11 (15e) is a potent and selective neuraminidase (NA) inhibitor with the IC₅₀ values of 4.7 nM, 8.46 nM and 1.5 nM against H1N1, H5N1 and H5N8 NAs respectively^[1].

Neuraminidase-IN-11 (15e) (0-6 μM, 40 min)has anti-NA (Neuraminidase) activity against H1N1-H274Y mutant and H5N1-H274Y mutant with the IC₅₀ values of 1.07 μM and 0.61 μM, respectively^[1].
Neuraminidase-IN-11 (15e) (0-20 μM, 48 h) inhibits chicken embryo fibroblasts (CEFs) infected H5N1 or H5N8 with the IC₅₀ values of 4.4 μM and 0.57 μM respectively, and inhibits Madin−Darby canine kidney (MDCK) cells infected H1N1 or H3N2 with the IC₅₀ values of 0.05 μM and 12.65 μM respectively^[1].
Neuraminidase-IN-11 (15e) has no significant inhibitory effect on the major CYP enzymes which acts on CYP1A2, CYP2C9 and CYP2C19 with the IC₅₀ values of 28.9 μM, 47.3 μM and 47.8 μM, respectively^[1].
The metabolic stability parameters of Neuraminidase-IN-11 (15e) in human liver microsomes (HLM)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Neuraminidase-IN-11 (15e) (oral administration, 50 mg/kg, every second day, 14 days) shows no significant change in body weight and no other toxic side effects in kunming mice^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

486.62

C₂₆H₃₄N₂O₅S

2685786-28-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Han Ju, et al. Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-Cavity. J Med Chem. 2022 Aug 8.  [Content Brief]