Nizofenone  (Synonyms: 尼唑苯酮；硝唑芬酮；米唑硝苯酮)

Nizofenone is a neuroprotective agent which protects neurons from death following cerebral ischemia or anoxia. Nizofenone can be used in the research of acute neurological conditions, such as stroke^[1][2][3].

Nizofenone (1 and 10 μM) prolongs the action potential duration of guinea-pig papillary muscle and dog Purkinje fibers^[3].
Nizofenone (30 μM) suppresses the spontaneous activity of dog Purkinje fibers and guinea-pigs S-A node^[3].
Nizofenone (100 μM) decreases the contractile force of guinea-pig papillary muscle^[3].
Nizofenone (10 μM) inhibits the peroxidative disintegration of mitochondria (in rat brain mitochondrial suspension)^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nizofenone (3 and 9 mg/kg, i.p., daily) attenuates the chronic restraint stress (CRS)-induced cognitive impairments^[1].
Nizofenone (10 mg/kg i.p.) inhibits ischemia-induced glutamate increase and lactate increase in the hippocampus of rats^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

412.87

C₂₁H₂₁ClN₄O₃

54533-85-6

尼唑苯酮；硝唑芬酮；米唑硝苯酮

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yi Liu, et al. Protective effects of nizofenone administration on the cognitive impairments induced by chronic restraint stress in mice. Pharmacol Biochem Behav. 2013 Jan;103(3):474-80.  [Content Brief]

  [2]. Y Matsumoto, et al. Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation. Eur J Pharmacol. 1994 Sep 1;262(1-2):157-61.  [Content Brief]

  [3]. Y Miura, et al. [Effects of nizofenone on the action potential of guinea-pig papillary muscle and S-A node and dog Purkinje fibers].  [Content Brief]

  [4]. H Yasuda, et al. Cerebral protective effect and radical scavenging action. J Neurochem. 1981 Oct;37(4):934-8.  [Content Brief]