2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. (Nle4)-α-MSH

(Nle4)-α-MSH 是一种黑素细胞刺激激素 α-MSH (HY-P0252) 的合成类似物。(Nle4)-α-MSH 能够使青蛙皮肤可逆变黑，并在热碱处理后表现出延长的活性。

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Custom Peptide Synthesis

(Nle4)-α-MSH Chemical Structure

(Nle4)-α-MSH Chemical Structure

CAS No. : 64887-70-3

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(Nle4)-α-MSH 相关抗体

Top Publications Citing Use of Products

查看 Melanocortin Receptor 亚型特异性产品:

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MC1R MC3R MC2R MC4R MC5R

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment[1].

IC50 & Target

tyrosinase; melanoma adenylate cyclase[1]
体外研究
(In Vitro)

(Nle4)-α-MSH shows a better bioactivity than α-MSH in frog skin bioassay, activation of mouse melanoma adenylate cyclase, and stimulation of mouse melanoma cell tyrosinase activity[1].
(Nle4)-α-MSH (0.1 nM; 0.5, 4, 8 h) stimulates tyrosinase activity in melanoma cells (NCTC 3960)[1].
(Nle4)-α-MSH (0.1 nM; 1-4 h) increases biological activity of melanotropins, indicating darkening response of frog skins[1].
(Nle4)-α-MSH (0.1 μg) also activates mouse melanoma adenylate cyclase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(Nle4)-α-MSH 相关抗体:
分子量

1646.85

Formula

C78H111N21O19
CAS 号
Sequence Shortening

Ac-SYS-{Nle}-EHFRWGKPV-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(Nle4)-α-MSH 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Nle4)-α-MSH64887-70-3Melanocortin ReceptorMC Receptorfrog skinheat-alkalimelanocyte-stimulating hormonetyrosinase activityadenylate cyclaseInhibitorinhibitorinhibit

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