2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. nor-Binaltorphimine

nor-Binaltorphimine  (Synonyms: Norbinaltorphimine; NorBNI)

目录号: HY-117040 纯度: 98.70%
COA 产品使用指南 技术支持

nor-Binaltorphimine 是 kappa-opioid receptor 的选择性拮抗剂。nor-Binaltorphimine 在体内有持久的作用。

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nor-Binaltorphimine Chemical Structure

nor-Binaltorphimine Chemical Structure

CAS No. : 105618-26-6

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规格 价格 是否有货 数量
1 mg ￥1050
In-stock
5 mg ￥2660
In-stock
10 mg ￥3750
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of nor-Binaltorphimine:

nor-Binaltorphimine 相关抗体

Top Publications Citing Use of Products

查看 Opioid Receptor 亚型特异性产品:

查看所有亚型
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

nor-Binaltorphimine is a selective antagonist of kappa-opioid receptor. nor-Binaltorphimine has a long-lasting effect in vivo[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
0.28 nM
Compound: norBNI
Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS binding assay
Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS binding assay
[PMID: 25593096]
CHO EC50
120 nM
Compound: 1, norBNI
Agonist activity at human recombinant mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay
Agonist activity at human recombinant mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay
[PMID: 20568781]
CHO IC50
2.9 nM
Compound: norBNI
Antagonist activity at mouse kappa opioid receptor-1 expressed in CHO cell membranes assessed as inhibition of U50,488H-induced [35S]GTPgammaS binding incubated for 60 mins by scintillation spectroscopic analysis
Antagonist activity at mouse kappa opioid receptor-1 expressed in CHO cell membranes assessed as inhibition of U50,488H-induced [35S]GTPgammaS binding incubated for 60 mins by scintillation spectroscopic analysis
[PMID: 27556704]
CHO EC50
380 nM
Compound: 1, norBNI
Agonist activity at human recombinant delta opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay
Agonist activity at human recombinant delta opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay
[PMID: 20568781]
CHO IC50
4.6 nM
Compound: norBNI
Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-induced ERK phosphorylation pre-incubated with compound before U69,593 stimulation for 10 mins
Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-induced ERK phosphorylation pre-incubated with compound before U69,593 stimulation for 10 mins
[PMID: 25593096]
CHO EC50
6 nM
Compound: 1, norBNI
Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay
Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay
[PMID: 20568781]
U2OS IC50
2.5 nM
Compound: norBNI
Antagonist activity against human kappa opioid receptor expressed in human U2OS cells co-expressing beta-arrestin2 pre-treated for 15 mins before U69,593 stimulation for 90 mins by DiscoveRx beta-arrestin2 recruitment based PathHunter assay
Antagonist activity against human kappa opioid receptor expressed in human U2OS cells co-expressing beta-arrestin2 pre-treated for 15 mins before U69,593 stimulation for 90 mins by DiscoveRx beta-arrestin2 recruitment based PathHunter assay
[PMID: 25593096]
分子量

661.79

Formula

C40H43N3O6
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

H2O 中的溶解度 : 33.08 mg/mL (49.99 mM; 超声加热助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5111 mL 7.5553 mL 15.1105 mL
5 mM 0.3022 mL 1.5111 mL 3.0221 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

nor-Binaltorphimine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.5111 mL 7.5553 mL 15.1105 mL 37.7763 mL
5 mM 0.3022 mL 1.5111 mL 3.0221 mL 7.5553 mL
10 mM 0.1511 mL 0.7555 mL 1.5111 mL 3.7776 mL
15 mM 0.1007 mL 0.5037 mL 1.0074 mL 2.5184 mL
20 mM 0.0756 mL 0.3778 mL 0.7555 mL 1.8888 mL
25 mM 0.0604 mL 0.3022 mL 0.6044 mL 1.5111 mL
30 mM 0.0504 mL 0.2518 mL 0.5037 mL 1.2592 mL
40 mM 0.0378 mL 0.1889 mL 0.3778 mL 0.9444 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

nor-Binaltorphimine105618-26-6Norbinaltorphimine NorBNIOpioid Receptorkappa-opioid receptorAntinociceptionInhibitorinhibitorinhibit

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