2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. NR160

NR160 是一种选择性 HDAC6 抑制剂，IC50 为 30 nM。NR160 对白血病细胞系具有较低的细胞毒性。NR160 显著促进 Bortezomib (HY-10227) (蛋白酶体抑制剂)、Epirubicin (HY-13624)、Daunorubicin (HY-13062A) 的凋亡 (apoptosis) 诱导作用。

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NR160 Chemical Structure

NR160 Chemical Structure

CAS No. : 2484895-50-1

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规格 价格 是否有货 数量
1 mg ￥1710
3 - 4 周
5 mg   询价  
10 mg   询价  

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Customer Review

NR160 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NR160 is a selective HDAC6 inhibitor with an IC50 value of 30 nM. NR160 shows low cytotoxicity against leukemia cell line. NR160 augments the apoptosis induction of Bortezomib (HY-10227) (proteasome inhibitor), Epirubicin (HY-13624) and Daunorubicin (HY-13062A) significantly[1][2].

IC50 & Target[1]

HDAC6

30 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CCRF-HSB-2 IC50
51.8 μM
Compound: 6l, NR-160
Cytotoxicity in human CCRF-HSB-2 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay
Cytotoxicity in human CCRF-HSB-2 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay
[PMID: 32803970]
HL-60 IC50
42.9 μM
Compound: 6l, NR-160
Cytotoxicity in human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay
Cytotoxicity in human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay
[PMID: 32803970]
Jurkat IC50
32.1 μM
Compound: 6l, NR-160
Cytotoxicity in human Jurkat cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay
Cytotoxicity in human Jurkat cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay
[PMID: 32803970]
K562 IC50
41.6 μM
Compound: 6l, NR-160
Cytotoxicity in human K562 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay
Cytotoxicity in human K562 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay
[PMID: 32803970]
MOLT-4 IC50
42.4 μM
Compound: 6l, NR-160
Cytotoxicity in human MOLT-4 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay
Cytotoxicity in human MOLT-4 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay
[PMID: 32803970]
SUP-B15 IC50
22.5 μM
Compound: 6l, NR-160
Cytotoxicity in human SUP-B15 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay
Cytotoxicity in human SUP-B15 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay
[PMID: 32803970]
TALL-1 IC50
49.4 μM
Compound: 6l, NR-160
Cytotoxicity in human TALL-1 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay
Cytotoxicity in human TALL-1 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay
[PMID: 32803970]
体外研究
(In Vitro)

NR160 (化合物 6I) (2.5 μM 和 5 μM; 24 小时) 诱导 α-微管蛋白乙酰化 (ac-α-微管蛋白)[1]。
NR160 (1-50 μM; 24 小时) 对 IC50s >20 μM 的白血病细胞系具有较低的细胞毒性[1]。
NR160 (2.5 μM, 5 μM; 24 小时) 增强硼替佐米、表柔比星和柔比星对 HL60 细胞的细胞毒性诱导[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NR160 相关抗体:

Cell Viability Assay[1]

Cell Line: HL60 cells
Concentration: 1-50 μM
Incubation Time: 24 hours
Result: Inhibited leukemia cell lines with IC50s of 49.4 μM (TALL-1), 51.8 μM (HSB-2), 42.4 μM (MOLT-4), 32.1 μM (Jurkat), 42.9 μM (HL-60), 22.5 μM (SUP-B15), and 41.6 μM (K562), respectively.
分子量

510.47

Formula

C25H21F3N6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NR160 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NR1602484895-50-1NR 160NR-160HDACHistone deacetylasesInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-139181
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