1. NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  2. Keap1-Nrf2 Heme oxygenase (HO) Reactive Oxygen Species
  3. Nrf2/HO-1 activator 3

Nrf2/HO-1 activator 3 (Compound C3a) 是 Nrf2 信号通路的激活剂,可促进 Nrf2 核易位并上调血红素加氧酶-1 HO-1 的表达。Nrf2/HO-1 activator 3 可在 H2O2 或高糖刺激的 H9c2 心肌细胞中抑制 ROS 和 MDA 的过度表达,抑制细胞活力和细胞克隆形成,从而发挥抗氧化活性。

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Nrf2/HO-1 activator 3 Chemical Structure

Nrf2/HO-1 activator 3 Chemical Structure

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nrf2/HO-1 activator 3 (Compound C3a) is the activator for Nrf2 signaling pathway that promotes the Nrf2 translocation into nuclei and upregulates the expression of heme oxygenase-1 HO-1. Nrf2/HO-1 activator 3 inhibits the overespression of ROS and MDA in H2O2- or glucose-stimulated H9c2 cardiomyocytes, inhibits the cell viability and colony formation, thereby exhibiting antioxidant efficacy[1].

分子量

474.51

Formula

C27H26N2O6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Nrf2/HO-1 activator 3
目录号:
HY-170867
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