2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. NT376

NT376 是 IIa 类 Histone deacetylases (HDAC) 的高效选择性抑制剂，其 IC50 值为 32 nM，在 HT-29 细胞中与 NT160 (HY-149285) 相似 (IC50= 46 nM)。NT376 有望用于各种癌症和中枢神经系统疾病 (CNS) 的研究，如阿尔茨海默氏症和亨廷顿氏病。

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NT376 Chemical Structure

NT376 Chemical Structure

CAS No. : 2820208-97-5

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NT376 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NT376 is a high potency and selectivity inhibitor of class-IIa Histone deacetylases (HDAC) with an IC50 value of 32 nM, similar to NT160 (HY-149285) (IC50= 46 nM) in HT-29 cells. NT376 is proming for research of various cancers and in the diseases of the central nervous system (CNS) such as Alzheimer’s and Huntington’s diseases[1].

IC50 & Target[1]

HDAC4

1.26 nM (IC50, HT-29 cells)

HDAC5

2.85 nM (IC50, HT-29 cells)

HDAC1

1483 nM (IC50, HT-29 cells)

HDAC11

4851 nM (IC50, HT-29 cells)

Class I/IIb

>4000 nM (IC50, HT-29 cells)

HDAC6

5035 nM (IC50, HT-29 cells)

体外研究
(In Vitro)

NT376 (1.26-5035 nM, 3 小时) 在 HT-29 细胞中对 IIa 类 Histone deacetylases (HDAC) (IC50=32 nM) 表现出高选择性和高效性，高于其他 HDAC 类别 (IC50= >4.0 µM)，在功能细胞实验中表现略优于 NT160 (HY-149285)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NT376 相关抗体:
分子量

436.40

Formula

C21H20F4N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NT376 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NT3762820208-97-5NT 376NT-376HDACHistone deacetylasesselectivityHT-29 cellscancersCNSAlzheimer’s diseaseHuntington’s diseaseInhibitorinhibitorinhibit

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目录号：
HY-163806
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