2. Vitamin D Related/Nuclear Receptor
  3. Nuclear Hormone Receptor 4A/NR4A
  4. Nurr1 agonist 12

Nurr1 agonist 12 (Compound 37) 是核受体相关蛋白 1 (Nurr1) 的激动剂，可激活 Nurr1 的转录活性，EC50 为 0.06 μM。Nurr1 agonist 12 可激活人类反应元件 NBRE、NurRE 和 DR5，EC50 分别为 0.07 μM、0.027 μM 和 0.014 μM。Nurr1 agonist 12 可诱导 Nurr1 调节的神经营养基因的表达，例如酪氨酸羟化酶 (TH)、SOD1/2、BDNF、Sestrin 3 和 BIRC5（Survivin）。 Nurr1 agonist 12 表现出对 Paraquat 引起的神经毒性的神经保护作用。

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Nurr1 agonist 12 Chemical Structure

Nurr1 agonist 12 Chemical Structure

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Nurr1 agonist 12 相关抗体

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查看 Nuclear Hormone Receptor 4A/NR4A 亚型特异性产品:

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Nur77/NR4A1 Nurr1/NR4A2

  • 生物活性

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生物活性

Nurr1 agonist 12 (Compound 37) is the agonist for nuclear receptor-associated protein 1 (Nurr1) that activates the transcriptional activity of Nurr1 with an EC50 of 0.06 μM. Nurr1 agonist 12 activates the human response elements NBRE, NurRE, and DR5 with EC50 of 0.07 μM, 0.027 μM, and 0.014 μM, respectively. Nurr1 agonist 12 induces the expression of Nurr1-regulated neurotrophic genes, such as tyrosine hydroxylase (TH), SOD1/2, BDNF, Sestrin 3, and BIRC5 (Survivin). Nurr1 agonist 12 exhibits neuroprotective efficacy against Paraquat-induced neurotoxicity[1].

IC50 & Target

Nurr1/NR4A2

0.06 μM (EC50)

分子量

321.76

Formula

C18H12ClN3O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nurr1 agonist 12 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nurr1 agonist 12Nuclear Hormone Receptor 4A/NR4ANuclear Hormone Receptor 4ANerve Growth Factor IB-like ReceptorAlzheimer's diseaseADParkinson's diseasePDInhibitorinhibitorinhibit

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