2. Neuronal Signaling
  3. Monoamine Oxidase
  4. NW-1772

NW-1772 (compound 22b) 是一种有效的选择性单胺氧化酶 (MAO) B 抑制剂。NW-1772 具有快速穿透血脑屏障、短效且可逆的抑制活性、对特定细胞色素 P450 的抑制轻微、体外毒性低等优点。 NW-1772 可用于神经退行性疾病的研究。

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NW-1772 Chemical Structure

NW-1772 Chemical Structure

CAS No. : 911290-35-2

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Other Forms of NW-1772:

NW-1772 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

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MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NW-1772 (methanesulfonate) (compound 22b) is a potent and selective monoamine oxidase (MAO) B inhibitor. NW-1772 has some advantages, such as rapid blood-brain barrier penetration, short-acting and reversible inhibitory activity, slight inhibition of selected cytochrome P450s, and low in vitro toxicity. NW-1772 can be used for the research of neurodegenerative diseases[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
SH-SY5Y IC50
29.7 μM
Compound: 22b
Cytotoxicity against human SH-SY5Y cells after 24 hrs by MTS assay
Cytotoxicity against human SH-SY5Y cells after 24 hrs by MTS assay
[PMID: 19810674]
分子量

425.88

Formula

C19H20ClNO6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NW-1772 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NW-1772911290-35-2NW1772NW 1772Monoamine OxidaseMAOmonoamine oxidase (MAO)MAO-Bblood-brain barrier penetrationcytochrome P450sneurodegenerative diseasesInhibitorinhibitorinhibit

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