Nα,Nα-Bis(carboxymethyl)-L-lysine 

Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC₅₀ of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study^[1][2][3].

Nα,Nα-Bis(carboxymethyl)-L-lysine (59 nM)使 H214A (T2R4 的组成型活性突变体) 的基础活性降低 40%^[1]。
Nα,Nα-Bis(carboxymethyl)-L-lysine (60 nM, 15 分钟) 可以阻断过表达 T2R4 和 Ga16/44 的 HEK293T 细胞中奎宁引起的 Rac1 基础活化状态的降低，但在 HEK293T 野生型细胞中没有这种阻断作用^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nα,Nα-Bis(carboxymethyl)-L-lysine (10 μM) 在成年 C57BL6/J 中对苦味物质的舔舐反应无影响^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

262.26

C₁₀H₁₈N₂O₆

113231-05-3

固体

White to off-white

Room temperature in continental US; may vary elsewhere.

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• [1]. Pydi SP, et al. Amino acid derivatives as bitter taste receptor (T2R) blockers. J Biol Chem. 2014;289(36):25054-25066.  [Content Brief]

  [2]. Sidhu C, et al. Regulation of Rac1 GTPase activity by quinine through G-protein and bitter taste receptor T2R4. Mol Cell Biochem. 2017;426(1-2):129-136.  [Content Brief]

  [3]. Masamoto M, et al. Yoshida R. Effects of bitter receptor antagonists on behavioral lick responses of mice. Neurosci Lett. 2020;730:135041.  [Content Brief]