2. Anti-infection
  3. Bacterial
  4. Obiltoxaximab

Obiltoxaximab  (Synonyms: 奥托萨昔单抗; ETI 204)

目录号: HY-P9932 纯度: 99.06%
COA

摩尔计算器

Obiltoxaximab (ETI 204) 是第二代有效的抗保护抗原 (PA) 单克隆抗体，具有免疫原性。动物模型中 Obiltoxaximab 在炭疽毒素组装和靶细胞中毒中起核心作用，促进存活，抑制细菌向外周扩散。Obiltoxaximab 可用于吸入性炭疽、菌血症和毒血症的研究。

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CAS No. : 1351337-07-9

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Obiltoxaximab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Obiltoxaximab (ETI 204) is the second and potent anti-protective antigen (PA) monoclonal antibody with immunogenicity. Obiltoxaximab plays a central role in anthrax toxin assembly and target cell intoxication, promoting survival, and inhibiting bacterial spread to the periphery in animal models. Obiltoxaximab can be used in the research of inhalational anthrax, bacteremia and toxemia[1][2][3][4].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Chimeric
体内研究
(In Vivo)

Obiltoxaximab (16 mg/kg, 静脉注射, 单次注射，持续 70 天) 对健康人群和受感染人群的模拟血清暴露与个体感染猕猴在注射Obiltoxaximab 后的总体血清暴露相当，在兔子实验中也有类似的结果[1]。
Obiltoxaximab (16 mg/kg, 肌肉注射, 在 B. anthracis spores 致死性攻击前 24、48、72 小时注射) 在食蟹猕猴中 B. anthracis spores 攻击后达到 100% 生存率，并预防绝大多数动物的系统性菌血症[2]。
Obiltoxaximab (4 和 8 mg/kg, 静脉注射和肌肉注射, 单次注射 9 小时) 暴露后预防 (PEP) 与 Levofloxacin (HY-B0330) 联用可导致兔子受到 B. anthracis spores 攻击后 100% 的生存率[2]。
Obiltoxaximab (8 mg /kg，静脉注射，单剂量，29 天) 联合抗生素或 Doxycycline (HY-N0565) 降低兔中炭疽保护抗原 (PA) 诱导的菌血症水平[5]。

肌肉注射 Obiltoxaxumab 的药代动力学[2]

Study and dose (mg/kg) Postchallenge dosing schedule Cmax (μg/mL) Tmax (days) AUC0-∞ (μg·day/mL) T1/2 (days) CL /F(mL/day/kg) Vz/F (mL/kg)
PEP 2
8 18 h 80.8 1.0 1030 7.50 7.76 84.0
8 24 h 86.5 1.0 788 5.20 10.2 76.2
16 18 h 165 1.0 2120 8.44 7.54 91.9
16 24 h 119 1.0 1990 9.85 8.03 114
PEP 3
16 24 h 142 1.0 2190 10.4 7.00 110
16 36 h 132 0.50 1540 7.09 10.0 106
16 48 h 104 3.0 2040 12.6 8.00 143

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human, macaques and rabbits[1]
Dosage: 16 mg/kg
Administration: i.v., a single dose, 70 days
Result: Overall serum exposures were comparable following obiltoxaximab in human, macaques and rabbits.
Animal Model: Cynomolgus macaques[2]
Dosage: 16 mg/kg
Administration: i.m., 24, 48, 72 h prior to lethal challenge with B. anthracis spores
Result: Resulted in transient low levels of bacteremia in several animals, resolving in all animals after day 4, and the majority of animals remained abacteremic until day 56.
Animal Model: Rabbits[2]
Dosage: 4 and 8 mg/kg
Administration: i.v. and i.m. at 4 and 8 mg/kg, a single dose, 9 h
Result: Effectiveness in the PEP setting was initially examined in rabbits.
Animal Model: Protective antigen (PA) of anthrax induced rabbits[5]
Dosage: 8 mg/kg
Administration: i.v., a single dose, 29 days
Result: Lowered bacteremia levels between days 1 and 2 combined with antibiotics, eliminated bacteremia levels combined with Doxycycline (HY-N0565) in protective antigen (PA) of anthrax induced rabbits.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

奥托萨昔单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献

Obiltoxaximab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

Obiltoxaximab1351337-07-9ETI 204奥托萨昔单抗ETI204ETI-204Bacterialanti-protective antigenimmunogenicityanthrax toxin assemblycell intoxicationinhalational anthraxbacteremiatoxemiaInhibitorinhibitorinhibit

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