2. Immunology/Inflammation
  3. CD20
  4. Ocrelizumab

Ocrelizumab  (Synonyms: 奥美珠单抗)

目录号: HY-P9960 纯度: 95.00%
COA

摩尔计算器

Ocrelizumab (Ocrevus) 是一种人源化抗 CD20 单克隆抗体。Ocrelizumab 可以通过抗体依赖性细胞毒性 (ADCC) 诱导 B 细胞耗竭并抑制多发性硬化症小鼠病变。

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CAS No. : 637334-45-3

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规格 价格 是否有货 数量
1 mg ￥3000
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5 mg ￥7800
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50 mg   询价  

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Ocrelizumab 相关抗体

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  • 生物活性

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生物活性

Ocrelizumab (Ocrevus) is a humanized anti-CD20 monoclonal antibody. Ocrelizumab can induce B cell depletion and inhibit multiple sclerosis lesions in mice through antibody dependent cytotoxicity (ADCC)[1][2].
体内研究
(In Vivo)

Ocrelizumab (7.5 mg/kg; 每天 1 次; 18 天; 皮下注射或静脉注射) 通过抗体依赖性细胞毒性 (ADCC) 诱导 B 细胞耗竭从而在多发性硬化症小鼠中抑制病变[1]。
Ocrelizumab (50 μg; 在第 7、14 和 21 天重复给药; 静脉注射) 在 C57BL/6 小鼠中可以减少血液、淋巴结和脾脏中的 B 细胞和 T 细胞[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HuCD20 mice with chronic DTH-TLS lesions[1].
Dosage: 7.5 mg/kg
Administration: Subcutaneous injection (s.c.) or intravenous injection (i.v.); once daily; 18 days; initiated on Days 63, 70 and 75 post lesion induction
Result: Reduced the number of CD19+ cells and MS like lesions in the spleen and lymph nodes of mice.
Animal Model: C57BL/6 mice [2].
Dosage: 50 μg
Administration: Intravenous injection (i.v.); repeat administration on days 7, 14, and 21
Result: Reduced the total CD19+ B cells and CD4, CD8 T cells in the blood, spleen, and LN.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

奥瑞利珠单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献

Ocrelizumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ocrelizumab637334-45-3奥瑞利珠单抗CD20Humanized antibodyB cell depletionmultiple sclerosisInhibitorinhibitorinhibit

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