2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. ODN 21158

ODN 21158 是一种有效的 G 修饰的 TLR3 和 TLR9 抑制剂。ODN 21158 没有细胞毒性。ODN 21158 以剂量依赖性方式抑制 IFN-α 分泌。

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DNA, d(P-thio)(C-C-T-G-G-C-G-G-G-G)

ODN 21158 Chemical Structure

CAS No. : 1964506-31-7

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Other Forms of ODN 21158:

ODN 21158 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ODN 21158 is a potent G-modified TLR3 and TLR9 inhibitor. ODN 21158 shows no cytotoxic. ODN 21158 inhibits IFN-α secretion in a dose dependent manner[1].

体外研究
(In Vitro)

ODN 21158 (0.01, 0.1, 1, 10 μM) shows no cytotoxic in human PBMCs[1].
ODN 21158 (0.01, 0.1, 1, 10 μM; 24 h) inhibits IFN-α secretion in a dose dependent manner when stimulated with CpG-ODN 2216 (3 μM) in Human PBMCs[1].
ODN 21158 (0.01, 0.1, 1, 10 μM; 48 h) stimulated with CpG-ODN 2006 (100 nM) failes to inhibit IL-6 release of PBMCs[1].
ODN 21158 (0.01, 0.1, 1, 10 μM; 48 h) inhibits the release of IL-6 when stimulated with imiquimod (5 μg/ml) in human PBMCs[1].
ODN 21158 (0.1, 1, 10 μM; 24 h) inhibits the release of IL-6 in B-cells when stimulated with imiquimod (5 μg/ml) and CpG-ODN 2006 (100 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ODN 21158 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: human PBMCs
Concentration: 0.01, 0.1, 1, 10 μM
Incubation Time: 48 h
Result: Did not result in increased levels of extracellular LDH and not reduced the intracellular ATP-levels of CpG-ODN 2006-stimulated PBMCs.
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ODN 21158 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ODN 211581964506-31-7ODN21158ODN-21158Toll-like Receptor (TLR)IFN-αIL-6B-cellsPBMCsInhibitorinhibitorinhibit

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产品名称：
ODN 21158
目录号：
HY-150739
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