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  3. ONO-AE 248

ONO-AE 248是一种选择性EP3受体激动剂,具有心脏保护活性。ONO-AE 248通过选择性结合小鼠EP3α受体,降低心肌梗死面积。ONO-AE 248的心脏保护作用与血流动力学效应无关。ONO-AE 248的机制可能涉及蛋白激酶C的激活和K(ATP)通道的打开。

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ONO-AE 248 Chemical Structure

ONO-AE 248 Chemical Structure

CAS No. : 211230-67-0

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  • 生物活性

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生物活性

ONO-AE 248 is a selective EP3 receptor agonist with cardioprotective activity. ONO-AE 248 reduces myocardial infarction size by selectively binding to the EP3α receptor in mice. The cardioprotective effect of ONO-AE 248 is independent of hemodynamic effects. The mechanism of ONO-AE 248 may involve activation of protein kinase C and opening of K(ATP) channels[1].

分子量

380.52

Formula

C22H36O5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

ONO-AE 248 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
ONO-AE 248
目录号:
HY-12184
需求量: