2. Immunology/Inflammation
  3. CD47
  4. Ontorpacept

Ontorpacept  (Synonyms: TTI-621)

目录号: HY-P99777 纯度: 99.57%
COA

摩尔计算器

Ontorpacept (TTI-621) 是一种可溶性融合蛋白，由人 SIRPα 的 N 端和人 IgG1 的 Fc 区域连接而成。Ontorpacept 的 N 端 (1-118) 片段是 CD47 的结合域，CD47 是巨噬细胞吞噬作用的抑制剂。Ontorpacept 是一种 CD47 阻断的检查点抑制剂，具有抗肿瘤活性。

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CAS No. : 2131089-46-6

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1 mg ￥5500
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Ontorpacept 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ontorpacept (TTI-621) is a soluble fusion protein that consists of the human SIRPα N-terminal (1-118) linked to the Fc region of human IgG1. The N-terminal (1-118)-fragment of ontorpacept is a binding domain for CD47 which is an inhibitor of phagocytosis by macrophages. Ontorpacept is a CD47-blocking checkpoint inhibitor with antitumor activity[1].

种属

Human
体外研究
(In Vitro)

Ontorpacept (0.001-1000 nmol/L；2 h) 在急性髓性白血病，骨髓增生异常综合征，多发性骨髓瘤，B 细胞急性淋巴细胞白血病和 T 细胞急性淋巴细胞白血病患者的肿瘤细胞样本中，剂量依赖性地增加肿瘤细胞的巨噬细胞吞噬作用，平均 EC50 为 10 nmol/L[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ontorpacept 相关抗体:
体内研究
(In Vivo)

Ontorpacept (8 mg/kg；腹腔注射，每周 3 次，共 4 周) 在 SCID 小鼠急性髓性白血病异种移植模型中具有抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD.SCID mice with AML cell transplants[1]
Dosage: 8 mg/kg
Administration: Intraperitoneal injection; 8 mg/kg, 3 times a week for 4 weeks
Result: Significantly reduced the tumor growth in bone marrow and spleen.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Homo sapiens SIRPA (signal regulatory protein alpha, SHPS1, SIRP, SIRPalpha)-IGHG1 (Fc (Fragment constant)
Biological Activity
  • Immobilized Ontorpacept can bind Human CD47 Protein (ECD, His Tag). The EC50 for this effect is 9.12 ng/mL.
纯度 & 产品资料
参考文献

Ontorpacept 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ontorpacept2131089-46-6TTI-621TTI621TTI 621CD47Cluster of Differentiation 47MER6OA3fusion proteinSIRPαIgG1phagocytosismacrophagecheckpoint inhibitorInhibitorinhibitorinhibit

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