2. GPCR/G Protein
  3. PTHR
  4. Osteostatin

Osteostatin  (Synonyms: PTHrP (107–111))

目录号: HY-P4684
产品使用指南

摩尔计算器

Osteostatin 是甲状旁腺激素相关蛋白 (PTHrP) 107-111 片段，促进骨缺损动物模型的骨修复，防止炎症性关节炎的骨侵蚀，抑制骨胶原诱导的关节炎和破骨细胞吸收。Osteostatin 可用于免疫炎症研究。

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Custom Peptide Synthesis

Osteostatin Chemical Structure

Osteostatin Chemical Structure

CAS No. : 138949-73-2

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Osteostatin 相关抗体

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PTH1R

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research[1][2][3][4].

体外研究
(In Vitro)

Osteostatin (100，250，500 nM，7-9 天) 以浓度依赖的方式降低破骨细胞的分化[2]。
Osteostatin (100，250，500 nM，7 天) 降低组织蛋白酶 K、破骨细胞相关 Ig 样受体 (OSCAR) 和NFATc1 的 mRNA 水平[2]。
Osteostatin (100，250，500 nM，2 天) 抑制破骨细胞分化中主转录因子 NFATc1 的核转位[2]。
Osteostatin (0.1-100 nM, 2 天) 显著促进骨细胞 MC3T3-E1 的生长[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Osteostatin 相关抗体:

Cell Differentiation Assay[2]

Cell Line: PBMCs are cultured with M-CSF and RANKL
Concentration: 100, 250 and 500 nM
Incubation Time: 7-9 days
Result: Decreased the differentiation of osteoclasts in a concentration-dependent manner, but it does not modify the resorptive ability of mature osteoclasts.

RT-PCR[2]

Cell Line: PBMCs are cultured with M-CSF and RANKL
Concentration: 100, 250 and 500 nM
Incubation Time: 7 days
Result: Decreased the mRNA levels of cathepsin K, osteoclast associated Ig-like receptor (OSCAR) and NFATc1.

Immunofluorescence[2]

Cell Line: PBMCs are cultured with M-CSF and RANKL
Concentration: 100, 250 and 500 nM
Incubation Time: 2 days
Result: Inhibited the nuclear translocation of the master transcription factor in osteoclast differentiation NFATc1.

Cell Proliferation Assay[3]

Cell Line: MC3T3-E1 cells
Concentration: 0-100 nM
Incubation Time: 2 days
Result: Significantly increased cell growth of MC3T3-E1 cells
体内研究
(In Vivo)

Osteostatin (80 或 120 μg/kg；在疾病发作后每天皮下注射，持续 13 天) 降低关节炎的严重程度及软骨和骨降解< sup >[4]。< br/>

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Collagen-induced arthritis in male DBA/1 mice[4]
Dosage: 80 or 120 μg/kg
Administration: After the onset of disease s.c. every day for 13 days
Result: Reduced serum IgG2a levels as well as T cell activation, with the downregulation of RORγt+CD4+ T cells and upregulation of FoxP3+CD8+ T cells in lymph nodes.
Decreased the levels of key cytokines, such as interleukin (IL)-1β, IL-2, IL-6, IL-17, and tumor necrosis factor-α in mice paws, whereas enhanced IL-10.
分子量

619.67

Formula

C27H41N9O8
CAS 号
Sequence

Thr-Arg-Ser-Ala-Trp
Sequence Shortening

TRSAW
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Osteostatin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Osteostatin138949-73-2PTHrP (107–111)PTHRParathyroid hormone receptorPBMCsosteoclastic boneNFATc1bone defectsArthritisInhibitorinhibitorinhibit

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