2. MAPK/ERK Pathway
  3. p38 MAPK
  4. p38-α MAPK-IN-5

p38-α MAPK-IN-5 (compound 4e) 是一种有效的 p38α 抑制剂，对 p38α、p38 β、p38γ、p38δ 的 IC50 分别为 0.1 nM、0.2 nM、944 nM、4100 nM。p38-α MAPK-IN-5 具有抗炎作用，并且具有用于哮喘和慢性阻塞性肺病 (COPD) 研究的潜力。

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p38-α MAPK-IN-5 Chemical Structure

p38-α MAPK-IN-5 Chemical Structure

CAS No. : 1443242-46-3

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p38-α MAPK-IN-5 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

p38-α MAPK-IN-5 (compound 4e) is a potent p38α inhibitor with IC50s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research[1].

IC50 & Target[1]

p38α

0.1 nM (IC50)

p38β

0.2 nM (IC50)

p38γ

944 nM (IC50)

p38δ

4100 nM (IC50)

分子量

679.86

Formula

C37H49N11O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

p38-α MAPK-IN-5 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

p38-α MAPK-IN-51443242-46-3p38 MAPKp38αp38 βp38γp38δRegioisomeric pyrazoleanti-inflammatory,?asthma and chronic obstructive pulmonary diseaseCOPDInhibitorinhibitorinhibit

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