2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. Palmostatin B

Palmostatin B 是一种酰基蛋白硫酯酶 1 和 2 (APT-1, APT-2) 抑制剂。Palmostatin B 降低 NRAS 突变黑色素瘤细胞系的细胞活力。Palmostatin B 抑制细胞 Ras 去棕榈酰化。

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Palmostatin B Chemical Structure

Palmostatin B Chemical Structure

CAS No. : 1233365-12-2

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Palmostatin B 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Palmostatin B is an Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitor. Palmostatin B reduces cell viability in a panel of NRAS mutant melanoma cell lines. Palmostatin B inhibits Ras depalmitoylation in cells[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
57 nM
Compound: Palm B
Reversible inhibition of human ABHD16A expressed in HEK293 cells preincubated for 30 mins followed by 40 fold compound dilution and subsequent 1-LG substrate addition and measured at 30 mins time interval for 120 mins by fluorometric assay
Reversible inhibition of human ABHD16A expressed in HEK293 cells preincubated for 30 mins followed by 40 fold compound dilution and subsequent 1-LG substrate addition and measured at 30 mins time interval for 120 mins by fluorometric assay
[PMID: 30613338]
HEK293 IC50
99 nM
Compound: Palm B
Inhibition of human ABHD16A expressed in HEK293 cells preincubated for 30 mins followed by 1-LG substrate addition and measured after 90 to 120 mins by fluorometric assay
Inhibition of human ABHD16A expressed in HEK293 cells preincubated for 30 mins followed by 1-LG substrate addition and measured after 90 to 120 mins by fluorometric assay
[PMID: 30613338]
分子量

376.53

Formula

C23H36O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Palmostatin B 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Palmostatin B1233365-12-2PhospholipaseNRASmelanoma cellMDCK cellacylation cycleInhibitorinhibitorinhibit

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